Project Grant R01MH139659
- The National Institute of Mental Health awarded The Johns Hopkins University $807,893 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct advanced magnetic resonance imaging research on neurovascular abnormalities in individuals with schizophrenia across the life span. The recipient will perform quantitative MR imaging at 7 Tesla field strength to test the hypothesis that cerebral microvasculature and cerebrospinal fluid circulation and clearance...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $726,312 on August 16, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct preclinical research on explore-exploit balance as a cross-species index of cognitive flexibility in relation to serious mental health conditions including schizophrenia and mood disorders. The recipient will use touchscreen cognitive tasks and computational modeling to measure explore versus exploit...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $167,473 on January 2, 2026, for a project grant under the Mental Health Research Grants program (CFDA 93.242) to measure neuroplastic effects of oscillation-locked transcranial magnetic stimulation. The research addresses treatment-resistant major depressive disorder, which affects more than 30 percent of individuals with MDD who show no response to two or more antidepressant interventions. The project...
- The National Institute of Mental Health awarded $615,444 to the Regents of the University of Minnesota on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop precise functional characterization of the developing infant brain using a clinical 7T MRI scanner. The award funds research to establish reliable quantitative neuroimaging methods for infants during their first year of life, addressing a gap in current knowledge about early brain functional organization...
- The National Institute of Mental Health awarded the University of California, Los Angeles $817,686 under the Mental Health Research Grants program (CFDA 93.242) on April 25, 2026, to investigate autonomic regulation of brain function and cognition in patients with first-episode schizophrenia and healthy individuals. The project examines how dysfunction in the autonomic nervous system mechanistically contributes to disorganized brain activity and cognitive impairment in schizophrenia, focusing on...
- The National Institute of Mental Health awarded the University of Rochester $437,496 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate blood-brain barrier and glymphatic clearance disruptions as biomarkers for schizophrenia spectrum disorders in mid- to late-life first episode psychosis. The research examines interactions among three barrier systems regulating trafficking between blood and brain: the blood-brain barrier, blood-cerebrospinal fluid...
- The National Institute of Mental Health awarded the Regents of the University of Minnesota $149,177 on February 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research into valuation mechanisms linking phasic and tonic dopamine dynamics and their role in flexible motivational engagement. The award funds a two-aim research project that uses a novel broadband dopamine measurement technique to analyze how dopamine fluctuates across fast phasic and slower tonic...
- The National Institute of Mental Health awarded the University of Pittsburgh $739,727 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop federated statistical harmonization and multivariate modeling frameworks for investigating altered brain aging patterns in individuals with severe mental illness and the modifying effects of metabolic syndrome. The project addresses methodological challenges in large-scale neuroimaging research by leveraging the ENIGMA...
- The National Institute of Mental Health awarded the University of Texas Health Science Center at Houston $777,176 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and test biomarker-supported prevention intervention for schizophrenia spectrum disorder in at-risk children. The project will recruit children aged 9 to 18 with significant family history of schizophrenia spectrum disorder and other modifiable risk factors but without subclinical or...
- The National Institute of Mental Health awarded The Johns Hopkins University $538,657 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop Neural Navigator, a standardized platform for quantifying circuit pathophysiology in patient-derived cerebral organoids using multi-electrode array recordings and machine learning-based modeling to decode psychiatric disorder signatures in schizophrenia and bipolar disorder. The project aims to establish reproducible...
The National Institute of Mental Health awarded the Regents of the University of Minnesota $719,832 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurometabolic dysfunction and cognitive training mechanisms in mid- to late-life schizophrenia. The recipient will conduct an accelerated longitudinal study quantifying brain chemistry in 81 individuals with schizophrenia and 81 healthy controls (aged 35–79) using 7 Tesla magnetic resonance spectroscopy to measure glucose metabolism and glutamatergic functioning in prefrontal and occipital cortex. Participants will undergo three scanning sessions at baseline, 18 months, and 30 months, followed by a fourth session at 32 months after cognitive training. The study population will be divided into three demographically balanced age cohorts of 27 participants per cohort per group. The work will re-recruit participants from a prior Psychosis Human Connectome Project dataset to provide additional longitudinal data. The research tests the hypothesis that dysregulation of glucose metabolism and glutamatergic signaling contributes to cognitive and visual impairments in schizophrenia and may normalize in response to cognitive training. Work is performed in Minneapolis, Minnesota. The period of performance runs from September 1, 2026, through July 31, 2031. This is a Project Grant, the standard assistance type for NIH research funding under NIMH's mission to transform understanding and treatment of mental illnesses through basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $719.8k | 9/2/26 |