Project Grant R01MH139654
- The National Institute of Mental Health awarded New York University $110,228 on October 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate hippocampal-neocortical coupling in memory consolidation. The funded research examines how hippocampal sharp-wave ripples facilitate communication between the hippocampus and neocortex during non-rapid eye movement sleep and support long-term memory consolidation. The project includes three parallel studies: analysis of...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $532,314 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how sleep pressure and circadian timing interact to impact hippocampal function and memory consolidation. The research examines how different periods...
- This $408,541 Project Grant was awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to Drexel University in Pennsylvania. The grant supports research to investigate the role of a subpopulation of neurons in the retrosplenial cortex in initiating sleep patterns that facilitate memory consolidation. The key objectives are to study the neural dynamics of these "Down-State Assembly" neurons and their involvement in...
- The National Institute of Mental Health awarded Drexel University $412,550 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a closed-loop functional magnetic resonance imaging study testing whether neural reactivation causally promotes long-term memory retention. The project establishes proof-of-principle for a real-time neuroimaging approach—closed-loop neural reinforcement—to manipulate distributed neural activity patterns during memory consolidation....
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. (Nathan S Kline Institute) $745,840 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to define optimal timing and cognitive states for memory consolidation during wakefulness and test causal mechanisms for targeted memory modulation. The research determines when memory consolidation maximally occurs during post-learning wakefulness by systematically decomposing awake...
- The National Institute of Mental Health awarded Florida State University $301,998 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on memory reactivation and its effects on episodic recall and brain function. The project, designated R01MH142884, examines how concurrent reactivation of multiple memories can modify hippocampal overlap in a predictable, experience-dependent manner to enhance episodic memory recall. The research investigates whether...
- The National Institute of Mental Health awarded the University of Pittsburgh $1,004,971 through the Mental Health Research Grants program (CFDA 93.242) on April 8, 2026, to develop a platform for measuring and analyzing brain activity, cognitive states, behavior, and physiology during multiday neural recordings in individuals undergoing surgical treatment for epilepsy. The project will integrate wearable technology and artificial intelligence for behavioral and physiological monitoring alongside...
- The National Institute of Mental Health awarded the University of Utah $402,802 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to elucidate the role of the hippocampus in motor memory using temporal interference stimulation. The recipient will conduct causal neuroimaging research testing whether the hippocampus contributes to motor learning in young healthy adults. The project uses temporal interference stimulation, a non-invasive deep neural stimulation...
- The National Institute of Mental Health awarded New York University $226,404 on September 3, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct experimental research examining how memory replay supports continual learning in the brain. The research tests two hypotheses: that the brain forms representations segregating context- and task-specific information while abstracting shared structure across tasks, and that replay supports continual learning by orthogonalizing...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate molecular, cellular, and circuit-level mechanisms of working memory maintenance. The recipient will conduct research across multiple biological scales to understand how working memory—the transient maintenance of past events in the brain for comparison with ongoing experiences—functions normally and becomes impaired...
The National Institute of Mental Health awarded The Trustees of the University of Pennsylvania $546,613 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate state modulation of hippocampal-mediated memory formation in the human brain. The research tests a psychophysiological state model to determine when awake hippocampal ripple events occur in humans, examining how neural activity patterns are replayed and reactivated during both sleep and wake periods to strengthen and consolidate long-term memories. The study addresses divergence between human findings and rodent models regarding the brain states associated with hippocampal ripple genesis, specifically investigating whether these ripples occur in transient offline states that fluctuate dynamically with natural awake arousal, and examining the mechanistic role of acetylcholine in modulating both arousal and ripple generation. Performance occurs in Philadelphia, Pennsylvania. The five-year project runs through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $546.6k | 8/31/26 |