This federal Project Grant award ID K08MH136415 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $189,540 award supports a 5-year research project to be conducted at the University of Pittsburgh to investigate the independent and combined effects of schizophrenia and cannabis use on terminal type-specific cannabinoid CB1 receptor expression and signaling in the dorsolateral prefrontal cortex, and the resulting...
This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $1,425,651 in funding to the University of Maryland, Baltimore (UMB) to support a research project investigating the neural circuit mechanisms underlying interactions between distinct learning systems in the brain. The project aims to identify task components that drive learning interactions, determine the neural activity dynamics in the prefrontal cortex during...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $656,121 to The Johns Hopkins University to investigate the impact of adolescent cannabis use on prefrontal cortex maturation and cognitive function. The key objectives of the research are to: 1) Identify the molecular and morphological changes in microglia induced by adolescent THC exposure via cannabinoid receptor type 1 (CNR1) signaling;...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on investigating the effects of early-life cannabinoid exposure on the development of the prefrontal cortex and cognitive behaviors in mice. The total funding amount is $1,433,155, with the award period running from June 1, 2024 to March 31, 2029. The key objectives of this research project are to: 1) reveal the spatial and...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) provides $350,000 in funding to Creighton University to investigate the developmental effects of environmental enrichment on the sensitivity to minor cannabinoid drugs such as delta-8-THC and CBD. The key objectives are to 1) determine if adolescent exposure to high- or low-novelty environments can alter the behavioral response to these cannabis-derived...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $197,235 to support a 4-year research program on the role of basal forebrain cholinergic signaling in cognitive flexibility. The award aims to investigate how acetylcholine input from the basal forebrain to the basolateral amygdala and lateral orbitofrontal cortex regulates behavioral parameters underlying reward-based reversal learning in...
This $245,625 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a preclinical drug development platform to create GABAA alpha5 receptor positive allosteric modulators (PAMs) to improve cognitive function in schizophrenia. The research aims to remediate the excitatory/inhibitory imbalance in hippocampal circuitry that contributes to cognitive deficits in schizophrenia. The proposed studies will test the...
This Project Grant award of $242,310 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research to investigate the role of reward mechanisms in episodic memory formation within the hippocampus. The research project, conducted by The Johns Hopkins University, will use in vivo electrophysiology to evaluate how expected and unexpected rewards influence head scanning behavior and the potentiation of hippocampal place fields...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $460,855.00 in funding to New York University School of Medicine to investigate the cellular and circuit mechanisms by which acetylcholine promotes associative learning in the primary somatosensory cortex. The key objectives of this 2-year award are to: 1) Use 2-photon microscopy to study the magnitude and time course of acetylcholine release in the...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $423,750 to Rockefeller University to advance research on the molecular programs in the thalamus that enable working memory. The goal is to delineate the chronic and acute gene regulatory mechanisms downstream of the orphan receptor GPR12 that promote and maintain working memory function. The research will also link GPR12 signaling to its role in...