Project Grant R01MH139498

Award Date 4/3/25
Completion Date 1/31/30
Dollars Obligated $736K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Memphis, TN 38105, USA
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The project aims to characterize thalamocortical disruption and abnormal neuronal activity in the auditory cortex of mouse models harboring genetic risk factors for schizophrenia, including 22q11.2 and 3q29 microdeletions. The research seeks to identify common mechanisms and manifestations of positive symptoms across different schizophrenia genetic risk factors. Outcomes from this 5-year project may help advance understanding and treatment options for schizophrenia by identifying convergent biological pathways and neuronal circuit dysfunctions underlying hallucinations and other psychotic symptoms.

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