This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants supports research to understand the neurobiological basis of schizophrenia and its impact on hippocampal network dynamics and spatial memory. The $231,547 award to George Mason University, a prominent research university, aims to investigate how NMDA receptor signaling regulates hippocampal oscillations and spatial memory retrieval. The study uses transgenic...
This $246,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research to measure brain lactate dynamics in individuals with first episode and chronic schizophrenia during a working memory task. The study aims to use functional magnetic resonance spectroscopy (fMRS) on a 3T clinical scanner to quantify lactate, glutamate, and blood oxygen level dependent (BOLD) changes in the brain in response to...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants, aims to develop a preclinical therapeutic platform to create GABAA alpha5 receptor positive allosteric modulators to improve cognitive function in schizophrenia. The $245,625 award to The Johns Hopkins University will advance drug development by testing the efficacy of two GABAA alpha5 receptor positive allosteric modulators to remediate the...
The National Institute of Mental Health (NIMH) awarded a $1,271,250 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Rockefeller University to investigate the molecular programs in the thalamus that enable working memory. The award, covering the period from August 1, 2024 to April 30, 2029, will fund research to delineate the chronic and acute gene regulatory programs downstream of a novel orphan receptor, GPR12, that modulates short-term memory in the thalamus. The goal is to...
This Project Grant award of $706,404 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at Thomas Jefferson University to investigate the role of protein-protein interactions in the pathophysiology of schizophrenia. The key objectives are to examine how alterations in specific protein-protein interactions within the NMDA receptor complex contribute to NMDAR hypofunction, a key synaptic pathology in...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242, Mental Health Research Grants, will support a 5-year, $775,706 study to investigate the neural mechanisms and functional impacts of reducing anticholinergic burden in mid- to late-life schizophrenia spectrum disorders (SSD). The study will enroll 80 SSD patients, ages 40-70, in a randomized controlled trial to assess the effects of anticholinergic medication reduction on cognition, quality of life,...
This $2,694,945 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to identify cellular phenotypes related to the etiology, pathophysiology, and symptomatology of schizophrenia. The Lieber Institute for Brain Development, a non-profit medical research organization, will utilize induced pluripotent stem cell (iPSC) technology to model the cumulative cellular effects of common schizophrenia genetic...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $429,000.00 in funding to Thomas Jefferson University to conduct research on cell-type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia. The goal of this 2-year project is to determine how Src kinase-mediated NMDA receptor signaling alterations are distinctly manifested in pyramidal neurons versus interneurons in the...
This federal Project Grant award of $647,833 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research conducted by Northwestern University to investigate cellular mechanisms underlying excitation/inhibition imbalance in the medial prefrontal cortex as a convergent pathogenic mechanism across genetic mouse models relevant to schizophrenia. The key research objectives are to: 1) determine the reversal potential of the...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,491,482 to investigate the neurobiological correlates of increased extracellular water volume, a recent neuroimaging finding in schizophrenia. The award aims to utilize a validated animal model and analyze existing patient data to characterize the relationship between neuroimaging biomarkers, blood biomarkers, and cognitive deficits in...