This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $678,430 to The Regents of the University of California, Berkeley (UC Berkeley) from September 2024 to June 2029. The award will fund research to investigate the role of the orbitofrontal cortex (OFC) in inhibiting habitual responses in the striatum to enable goal-directed decision-making. The project will use novel behavioral tasks and advanced...
This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $446,627 to the University of California, San Diego to conduct research on the function of the subiculum region of the brain and its role in spatial cognition and navigation. The research aims to systematically investigate orientation tuning and encoding of directional information in the subiculum, with a focus on how this brain region supports flexible navigation...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a research project to study the neural circuit mechanisms underlying observational spatial working memory in rats. The $1,008,906 award to Baylor College of Medicine will support behavioral testing, simultaneous high-density neural recordings, and closed-loop electrical/optogenetic manipulations to determine key behavioral factors, neural...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to determine how model-based decision-making is represented in distinct cell types within the prelimbic cortex and dorsomedial striatum, two brain regions implicated in compulsive disorders. The $189,540 award, which runs from February 1, 2025 to January 31, 2030, will fund in vivo electrophysiology and optogenetics...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $484,546 to Northwestern University to conduct research on "Transformation of Value in the Basal Ganglia". The project aims to investigate how the brain integrates information about the costs and benefits associated with foraging decisions and how this is encoded in the basal ganglia neural circuits. Key activities include developing a...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $338,600 to The Trustees of Columbia University in the City of New York, from August 1, 2024 to June 30, 2027. The project aims to use computational modeling and human single-neuron recordings to demonstrate the neural circuits that underlie egocentric and allocentric cognitive maps in humans. The research will analyze how spatial cells...
The National Institute of Mental Health (NIMH) awarded a $431,750 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine (UC Irvine) to investigate the role of the medial striatum in spatial sequence learning and its interaction with the hippocampus. The two-year study, running from September 1, 2023 to August 31, 2025, aims to evaluate how the dorsomedial striatum contributes to the disambiguation of repeated spatial traversals that occur in distinct...
The National Institute of Mental Health (NIMH) awarded a $625,108 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine (UCI) to conduct research on understanding the output circuits of the lateral entorhinal cortex and their role in associative memory formation. The 5-year project, which began on March 17, 2025, aims to identify the circuit mechanisms for how the entorhinal-hippocampal system enables the encoding and retrieval of declarative...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research aimed at understanding the neural substrates of context-dependent decision-making in mice. The $252,125 award, spanning September 2024 to March 2028, will leverage whole-brain functional magnetic resonance imaging (fMRI) and advanced optogenetic techniques to: 1) identify brain regions involved in the maintenance of contextual information,...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $781,119 to The Regents of the University of California, San Francisco (UCSF) to conduct research on "Dissecting the Circuits and Population Dynamics that Represent Unconditioned and Conditioned Stimuli in the Ventral Hippocampus". The research aims to understand how ventral CA1 neurons in the hippocampus acquire, update, and...