Project Grant R01MH137047

Award Date 9/3/24
Completion Date 6/30/29
Dollars Obligated $1.3M
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
Ithaca, NY 14853, USA
Similar Awards
The National Institute of Mental Health (NIMH) awarded a $679,118 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Santa Cruz (UCSC) to study the cellular and circuit mechanisms underlying the long-lasting therapeutic effects of the psychedelic drug psilocybin in the stressed brain. The project aims to determine how psilocybin affects synaptic plasticity, cortical functional networks, and the representation of behavioral variables in the stressed...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $246,000.00 to The Trustees of Princeton University to investigate the brain mechanisms underlying the therapeutic potential of psilocybin. The research aims to: 1) examine the accelerated acquisition of motivated behavior and task performance after psilocybin administration, and 2) identify the cellular and brain-wide substrates driving...
This federal Project Grant award for $708,511 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a mechanistic trial to elucidate the effects of psilocybin on neural activity in individuals with alcohol use disorder (AUD). The study aims to evaluate the impacts of high-dose versus low-dose psilocybin on AUD patients' neural response to negative affective stimuli and alcohol cues, as well as subsequent drinking...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at the University of Oregon to investigate the polypharmacology and psychoplastogenic effects of psychedelic drugs using the C. elegans model organism. The overarching goal is to determine how representative psychedelic compounds, which primarily activate serotonin receptors, influence behavior and neuroplasticity in this invertebrate...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research to investigate the neural dynamics underlying brain state-dependent memory functions. The $797,402 award to Cornell University, from July 2025 to April 2030, will involve simultaneously monitoring memory reactivation and brain states/substates in naturally sleeping mice after a hippocampal-dependent memory task. The research aims to...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the federal Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund a feasibility clinical trial to develop and evaluate a Psilocybin-Assisted Cognitive Behavioral Therapy (PA-CBT) protocol for treating major depressive disorder. The $236,250 award, granted on December 17, 2024, supports a 3-year study to refine and optimize the PA-CBT approach, and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $128,000 to the Boston VA Research Institute, Inc. to investigate the neural mechanisms underlying abnormal spontaneous gamma activity (SGA) in schizophrenia and translational mouse models. The research aims to determine if increased SGA in schizophrenia and in mouse models induced by ketamine administration or optogenetic stimulation of...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $306,556 Project Grant under CFDA 93.286 - "Discovery and Applied Research for Technological Innovations to Improve Human Health" to Interval Therapeutics LLC. The grant supports the development of bioresorbable microdevices that deliver intermittent sub-perceptual doses of 5HT2A agonists, such as psilocybin, to mitigate depression associated with opioid use disorder (OUD). The key aims are to produce...
The National Institute of Mental Health (NIMH) awarded a $1,380,070 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Duke University to explore the cellular properties and circuit functional roles of human cortical interneurons. This research aims to generate a multimodal phenotypic catalog of human interneurons and characterize their functional organization in neural circuits. The project will utilize live brain specimens collected from neurosurgical procedures and a novel genetic...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,516,931 to support translational research on the neurobiological circuit mechanisms underlying auditory hallucinations. The award to The Trustees of Columbia University will fund a multidisciplinary project that combines computational modeling, human neuroimaging, and mouse studies to elucidate the role of dopaminergic signaling in the dorsal...

This $1,255,890 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports research at Cornell University to investigate the role of cortical GABAergic interneurons in the effects of the psychedelic drug psilocybin.

The key objectives are to: 1) use cell type-specific electrophysiology to measure how the three major subtypes of GABAergic interneurons in the mouse medial frontal cortex respond to psilocybin administration; 2) determine if serotonin receptors expressed in the interneurons mediate psilocybin's plasticity-promoting actions; and 3) test if manipulating interneuron activity alters psilocybin's effects on stress-related behaviors. This research aims to provide insights into how the excitatory-inhibitory microcircuit shapes psilocybin's actions in the neocortex and identify cell types essential for psilocybin's effects on neural plasticity and behavior. The award period runs from Sep 3, 2024 to Jun 30, 2029.

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