This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,181,744 in funding to The Trustees of the University of Pennsylvania to conduct research on the molecular and circuit mechanisms by which a genetic risk factor, neurexin1a (NRXN1a), contributes to goal-directed dysfunction across multiple neuropsychiatric disorders. The research will examine how NRXN1a functions within midbrain dopamine neurons and striatal cholinergic interneurons to alter striatal neuromodulatory signals, and how these changes impact reinforcement processes and choice flexibility in value-based decision making. The work will employ cell type-specific NRXN1 deletion, slice electrophysiology, in vivo imaging, and optogenetic manipulations to understand the underlying neurobiology. This 5-year project aims to provide insights into the diverse goal-directed deficits seen across neuropsychiatric disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $727.2k | 6/16/25 | ||
| Not listed | $727.2k | 9/24/24 | ||
| Not listed | $727.2k | 9/24/24 |