Project Grant R01HL188369
- The National Heart Lung and Blood Institute awarded Northwestern University $2,139,171 under Project Grant R01HL184083 on September 1, 2026, to conduct epidemiological and mechanistic research linking ectopic fat with inflammation and atherosclerosis. The research addresses gaps in understanding how distinct fat depots—hepatic, visceral, epicardial, and pericoronary—drive local vascular inflammation and coronary plaque formation across populations. Northwestern will leverage two...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Kaiser Foundation Hospitals $3.92 million through the Cardiovascular Diseases Research program (CFDA 93.837) on September 27, 2025, for the HIDDEN-ASCVD (Harnessing Artificial Intelligence and Deep Learning to Determine a Coronary Artery Calcium Estimate in Patients with No History of Atherosclerotic Cardiovascular Disease) Study, with completion scheduled for August 31, 2029. The project leverages deep...
- The National Institute of Health's National Heart, Lung, and Blood Institute awarded Beth Israel Deaconess Medical Center $1,428,210 on September 15, 2025, under CFDA 93.837 (Cardiovascular Diseases Research) to conduct comprehensive proteomics profiling identifying novel circulating protein biomarkers of youth-onset type 2 diabetes and characterizing age-specific disease progression determinants. The recipient will perform multi-plex oligonucleotide-conjugated antibody-based proteomics...
- The National Heart, Lung, and Blood Institute awarded Icahn School of Medicine at Mount Sinai $1.669 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) for data-consistent motion-correction reconstruction of PET/MR imaging targeting coronary atherosclerotic plaque activity. The research addresses motion artifacts that degrade spatial resolution and quantitative accuracy in coronary PET imaging, particularly for low-count tracers such as 68GA-DOTATATE....
- The National Heart, Lung, and Blood Institute awarded Emory University $651,762 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct the RECHARGE: Imaging Ancillary Study, a noninvasive coronary imaging investigation nested within two ongoing PCORI-funded randomized controlled trials (RECHARGE:WOMEN and RECHARGE:MINORITIES). The study will leverage 600 women and 600 Black or Hispanic patients enrolled across 100 sites in the United States and Canada...
- The National Heart, Lung, and Blood Institute awarded the University of California, Los Angeles $1.564 million on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of long noncoding RNAs and micropeptides in inflammation, lipid metabolism, and atherosclerosis. The project spans two research aims. Aim 1 examines a macrophage micropeptide named BRIK, testing its role in integrating metabolic and immune signaling and its contribution to...
- The National Heart, Lung, and Blood Institute awarded New York University $6,557,762 on September 12, 2025, under CFDA 93.837 (Cardiovascular Diseases Research) to investigate the relationship between the gut microbiome and coronary artery calcium as a measure of subclinical coronary atherosclerosis in Asian American, Native Hawaiian, and Pacific Islander adults. The research aims to characterize coronary atherosclerotic burden in 4,000 ASA-NHPI adults aged 40 and older, integrating bacterial,...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $363,556 on February 23, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct secondary cross-sectional analyses examining the association between body composition and patient-centered outcomes in advanced interstitial lung disease. The funded research will analyze data from two prospective cohort studies to define how obesity and...
- The National Heart, Lung, and Blood Institute awarded Case Western Reserve University $109,076 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop improved cardiovascular risk prediction models using advanced computational methods applied to cardiac CT imaging. The research applies deep learning to detect small, low-density calcifications on coronary artery calcium score exams that are predictive of early-stage atherosclerosis and near-term...
- The National Institutes of Health National Heart, Lung and Blood Institute awarded Boston Children's Hospital $1,628,604 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct molecular research on atherosclerosis regulation, with performance through June 30, 2028. The project investigates endothelial dysfunction and chronic inflammation as critical regulators of plaque destabilization in atherosclerosis, focusing on the role of CD47 as a cell-surface...
The National Heart Lung and Blood Institute awarded the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center $852,991 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a longitudinal study of coronary inflammation detection using computed tomography. The recipient will measure epicardial fat density and peri-coronary fat attenuation in 17,138 non-contrast cardiac CT scans drawn from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, comprising 6,814 participants in the baseline study and scans from four subsequent exams (approximately 2-year intervals). The study examines whether fat beds around the heart and coronaries serve as biomarkers for atherosclerotic cardiovascular disease risk independent of coronary artery calcium scores, and whether non-contrast CT scans can function as a dual source for both coronary calcification and inflammation or visceral fat measurement. The work leverages over 20 years of validated follow-up data and repeat imaging across a multi-ethnic, comprehensively phenotyped population. The goal is to develop risk-stratification strategies targeting inflammation to reduce cardiovascular disease development and better personalize preventive treatment. Performance takes place in Torrance, California. The award runs through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $853.0k | 8/6/26 |