Project Grant R01HL184083
- The National Heart, Lung, and Blood Institute awarded Northwestern University $2,162,045 under Cardiovascular Diseases Research (CFDA 93.837) on September 15, 2025, for research characterizing apolipoprotein proteoforms and their relationships with cardiometabolic health and coronary heart disease events. The research objective is to characterize the full spectrum of apolipoprotein post-translational modifications in human plasma and to quantify their associations with adiposity, insulin...
- The National Heart Lung and Blood Institute awarded the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center $852,991 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a longitudinal study of coronary inflammation detection using computed tomography. The recipient will measure epicardial fat density and peri-coronary fat attenuation in 17,138 non-contrast cardiac CT scans drawn from the Multi-Ethnic Study of Atherosclerosis...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,597,024 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 1, 2026, to investigate mitochondrial quality control mechanisms in donor heart endothelial and smooth muscle cells as a strategy to improve cardiac allograft survival and reduce cardiac allograft vasculopathy following heart transplantation. The research addresses the acute and chronic phases of transplant injury:...
- The National Heart Lung and Blood Institute awarded Northwestern University $104,928 for a Project Grant (K99HL188111) on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research targeting lipid signaling pathways in perivascular interstitial macrophages as a therapeutic strategy for pulmonary fibrosis. The investigator will use single-cell spatial transcriptomics and RNA sequencing to characterize how perivascular interstitial macrophages...
- The National Heart Lung and Blood Institute awarded Northwestern University $654,762 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate regulatory T cell mechanisms limiting persistent inflammation during recovery from viral pneumonia. The award funds research into how FOXP3+ regulatory T cells orchestrate lung repair after viral pneumonia through expression of suppressive mediators, particularly the anti-inflammatory cytokine interleukin-10. The...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $696,259 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop flexible electronics and optogenetics approaches for real-time arrhythmic profiling of engineered heart tissues. The project runs through April 30, 2031, with work performed in Chicago, Illinois. The award funds development of non-invasive arrhythmia assessment methods for human induced pluripotent stem cell–derived...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $684,570 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate a bioengineered mitochondrial therapy platform for endothelial repair in vascular surgery. The research addresses endothelial injury, a fundamental barrier in vascular procedures that contributes to post-operative complications including vein graft failure, restenosis, and thrombosis. Northwestern's...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $812,196 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2026, to conduct research on targeted NAD+ replenishment as pre- and post-bypass therapy against vein graft failure. The research addresses the clinical problem that up to 20 percent of vein grafts fail within the first year following bypass surgery, and nearly half are occluded by 10 years. The award funds investigation of...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,589,058 under the Cardiovascular Diseases Research program (CFDA 93.837) on June 25, 2026, to support research on disordered mitochondrial proteostasis and alveolar epithelial repair in aging lungs. The project investigates how age-related dysfunction in mitochondrial complex I impairs lung recovery following viral pneumonia, with a focus on the role of alveolar epithelial type 2 cells in epithelial repair and the...
- The National Heart, Lung, and Blood Institute awarded Wake Forest University Health Sciences $2.402 million on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to map the molecular and cellular conversion of normal human coronary artery tissue to atherosclerotic plaque and identify therapeutic targeting opportunities for atherosclerotic vascular disease. The recipient will leverage its existing tissue biorepository of human coronary and aortic samples from trauma...
The National Heart Lung and Blood Institute awarded Northwestern University $2,139,171 under Project Grant R01HL184083 on September 1, 2026, to conduct epidemiological and mechanistic research linking ectopic fat with inflammation and atherosclerosis. The research addresses gaps in understanding how distinct fat depots—hepatic, visceral, epicardial, and pericoronary—drive local vascular inflammation and coronary plaque formation across populations. Northwestern will leverage two well-phenotyped cohorts: the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study and the Miami Heart Study, obtaining harmonized coronary CT angiography to quantify hepatic fat, epicardial adipose tissue, pericoronary fat attenuation index as a measure of perivascular inflammation, and coronary plaque. The research framework posits that dysregulated peripheral blood mononuclear cell inflammatory programs mediate the effect of specific ectopic fat depots on vascular inflammation and atherosclerosis. The project operates under the Cardiovascular Diseases Research program (CFDA 93.837), which supports heart and vascular research in basic, translational, clinical, and population sciences. Work is performed in Chicago, Illinois, with a period of performance extending from September 1, 2026, through May 31, 2031. The award is a Project Grant, a type of assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 8/28/26 |