Project Grant R01HL178710
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $720,399 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver. The 5-year project, running from Sep 1, 2025 to May 31, 2030, will investigate the associations between maternal microbiomes, metabolomes, and cardiovascular health outcomes in a racially and ethnically diverse pregnancy cohort. Key objectives are to characterize...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- The Project Grant award of $300,000.00 from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) will support a study on the epidemiology of the gut-liver axis and its relationship to hepatocellular carcinoma (HCC) risk in a multiethnic liver cirrhosis cohort. The study aims to expand the existing Microbiome, Microbial Markers, and Liver Disease (M3LD) cohort by enrolling approximately 1,000 participants with liver cirrhosis, with a focus on...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $639,151 to Augusta University Research Institute, Inc. to investigate sex differences in the gut microbiome, immune system, and their role in salt-sensitive hypertension and kidney disease. The research will be conducted using Dahl salt-sensitive rat models and human samples from an opposite-sex twin cohort. The key...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is supporting research to investigate how gut microbe-derived lipids, specifically N-acyl amides, can signal through the host receptor GPR119 to impact inflammatory and metabolic pathways related to cardiometabolic diseases like obesity and atherosclerosis. The $743,302 award to the Cleveland Clinic Lerner College of Medicine of Case Western...
- This federal Project Grant award of $856,580 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 5-year research project to investigate the relationship between the gut microbiome and Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project aims to elucidate the microbial origins of AD/ADRD in the Latino population, which has double the risk of AD/ADRD compared to non-Latino whites. Key...
- This $252,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to examine the relationship between menopausal hormone therapy, the gut microbiome, and estrogen-related outcomes in women with HIV. The study, to be conducted by the Albert Einstein College of Medicine, will perform shotgun metagenomic sequencing of gut microbiome samples collected before and after a 12-week randomized, double-blinded,...
- This $421,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to elucidate how lifestyle factors such as diet, exercise, and social interactions shape the gut microbiome's contributions to human metabolic health. Over the 5-year grant period from September 2025 to June 2030, the research will be conducted by the President and Fellows of Harvard College. The...
- This federal Project Grant award for $694,824 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to investigate the relationship between the gut microbiome and age-related joint degeneration, or osteoarthritis (OA). The research, conducted by the University of California, San Francisco (UCSF), will focus on examining how changes in the gut microbiome during aging may influence the development of spontaneous, age-related joint degradation. Key...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $399,174 to the University of Toledo to develop and utilize an innovative microfluidic tri-culture model. This model enables side-by-side co-culturing of anaerobic gut bacteria, colonic epithelial cells, and vagal sensory neurons to study the mechanistic pathways linking gut dysbiosis, colonic serotonin signaling, and vagal afferent 5-HT3 receptor activation in...
This Project Grant award of $2,177,784.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the relationship between the gut microbiome and coronary artery calcium (CAC), a marker of atherosclerosis, in Asian American, Native Hawaiian, and Pacific Islander (ASA-NHPI) populations. The study will leverage the existing MOSAAIC cohort of over 10,000 ASA-NHPI participants to characterize the current coronary atherosclerosis burden and examine how the gut microbiome, beyond traditional risk factors, may influence cardiovascular disease in these populations. The award will support research activities at New York University, the prime recipient, from September 2025 through June 2029. This study represents a crucial effort to better understand cardiovascular health disparities in the ASA-NHPI community and inform targeted prevention strategies through a microbiome-informed approach.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 9/15/25 |