Project Grant R01HL185247
- The National Heart, Lung, and Blood Institute awarded $1,137,435 to the University of Pennsylvania on March 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to advance therapeutic gene-editing approaches for cardiovascular and inherited disease. The recipient is developing and translating gene-editing therapies across three therapeutic domains. The first targets liver-centered, multiplex editing to prevent atherosclerotic cardiovascular disease through tunable...
- The National Heart, Lung, and Blood Institute awarded The Trustees of The University of Pennsylvania $198,728 on March 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop generative and multimodal artificial intelligence methods for aortic disease research. The funded work addresses gaps in understanding how aortic structure changes with age and disease by developing novel AI methods to simulate three-dimensional aortic remodeling patterns and creating...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $237,153 on August 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to advance predictive modeling of hospitalizations and emergency department visits for heart failure patients in managed long-term care settings through analysis of audio-recorded telephone communications between patients and care coordinators. The project, HEAR-HEARTFELT (Identifying the Risk of Hospitalizations or...
- The National Heart, Lung, and Blood Institute awarded $1,476,944 to the University of Pennsylvania on September 25, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop cardiovascular disease risk prediction models tailored to men with prostate cancer and determine their clinical impact. The award funds development of CVD absolute risk prediction models that incorporate cancer-specific variables, cardiotoxic cancer treatment effects including androgen deprivation...
- The National Heart Lung and Blood Institute awarded the University of Pennsylvania $169,020 on April 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the genomic and clinical mechanisms of myocardial lipomatous metaplasia and its prognostic implications for cardiac dysfunction and arrhythmia. The recipient will apply a deep-learning segmentation model to cardiac CT images from the Penn Medicine Biobank (23,940 participants with genotypes and imaging as of...
- The National Heart, Lung, and Blood Institute awarded The Trustees of the University of Pennsylvania $632,081 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop conformation-sensitive platelet-hitchhiking lipid nanoparticles for targeted delivery of mRNA and small interfering RNA to infarcted heart tissue following myocardial infarction. The project addresses therapeutic limitations in post-infarction recovery by engineering lipid nanoparticles to...
- The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $758,972 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, Project Grant R01HL187185) to investigate overlooked socioeconomic determinants of adolescent cardiovascular health, specifically examining how family wealth, assets, and debts influence cardiovascular risk factors in youth. The research addresses the gap in existing scholarship by focusing on wealth as an economic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded the University of Pennsylvania a $744,692 Project Grant on August 15, 2025, to investigate the mechanical regulation of cardiac growth and remodeling through Versican (VCAN) and G Protein-Coupled Receptor 126 (GPR126) signaling. The research will advance understanding of how mechanical forces generated by heart contractions direct...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $177,822 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify strategies for improving allergen mitigation among adults with persistent asthma to decrease disease morbidity. The award funds career development for a candidate investigator conducting qualitative research and implementation science to address three primary aims: determining barriers and facilitators to...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $243,750 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, Assistance Listing designation R03HL185220) to support research on occult hypoxemia prediction and long-term outcomes. Dr. Christopher Chesley will conduct a pilot study of prospectively enrolled critically ill adults receiving arterial lines during routine care in a high-volume medical intensive care unit. Through...
The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $685,212 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop policy-relevant evidence on the scope and effects of prior authorization (PA) for cardiovascular care. The project quantifies patient exposure to PA for cardiovascular services from 2016 through 2024, identifying which patient groups experience PA barriers and measuring how PA affects service use, care delays, and health outcomes. The research leverages administrative data from UnitedHealth, the nation's largest Medicare Advantage insurer, including PA policies, medical claims, and enrollment data for Medicare Advantage and commercial plans. The study exploits a natural experiment: in 2017, UnitedHealth implemented a PA reduction pilot across 71 Medicare Advantage plans in 9 states, eliminating PA requirements for over 300 services, with the most substantial reductions targeting cardiovascular-related services such as echocardiography. This quasi-experimental design generates causal evidence on PA's effects on cardiovascular service delivery and patient outcomes. Work is performed in Philadelphia, Pennsylvania, with a performance period extending through April 30, 2030. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $685.2k | 8/6/26 |