Project Grant R01HL187185
- The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $756,607 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research leveraging nutrient sensing and lysosomal degradative capacity in macrophages as a therapeutic approach to cardiovascular disease. The project addresses atherosclerosis, the underlying cause of myocardial infarction, strokes, and heart failure, by investigating dysfunction in the autophagy-lysosome system...
- The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $110,799 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a Midcareer Award in Patient-Oriented Research led by Andrea Goldschmidt, Ph.D., a clinical psychologist. The award funds the Ambulatory Study of Stress, Eating, and Reactivity in Teens (PROJECT ASSERT), which examines the intersection of obesity and eating disorders in adolescents and the role of...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $685,212 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop policy-relevant evidence on the scope and effects of prior authorization (PA) for cardiovascular care. The project quantifies patient exposure to PA for cardiovascular services from 2016 through 2024, identifying which patient groups experience PA barriers and measuring how PA affects service use, care...
- The National Heart, Lung, and Blood Institute awarded the University of Denver $169,638 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate neighborhood food access as a predictor of cardiovascular disease risk in early childhood. The project applies a prospective mechanistic approach to test whether limited neighborhood food access associates with obesogenic food-related behaviors and higher cardiovascular disease risk in early childhood. The...
- The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $767,953 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop biomimetic engineered heart valve leaflets that improve function and tissue remodeling. Work extends through March 31, 2030, and is performed in Pittsburgh, Pennsylvania. The project addresses clinical failures in tissue-engineered heart valves (TEHVs) deployed in pediatric patients, where pulmonary...
- The National Heart, Lung, and Blood Institute of the Department of Health and Human Services awarded Duke University $1,532,545 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to analyze the effect of income-based health insurance benefit designs on cardiovascular disease outcomes and disparities among low-income workers. The research examines whether employers' selective provision of more generous health benefits—such as free cardioprotective medicines or low...
- The National Institutes of Health National Heart Lung and Blood Institute awarded the University of Pittsburgh $198,728 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sex-specific differences in the remodeling of biopolymer-based tissue-engineered vascular grafts. The research addresses elevated coronary artery bypass graft failure rates in post-menopausal women compared to pre-menopausal women and men by examining vascular smooth muscle...
- The National Heart, Lung, and Blood Institute awarded $782,341 to the University of Pittsburgh on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate an adaptive, artificial intelligence-guided, closed-loop neuromodulation system for real-time prediction and prevention of ventricular arrhythmias in patients with prior myocardial infarction. The system will coordinate spinal cord stimulation and selective cardiac vagus nerve stimulation to...
- The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $248,967 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research dissecting vascular reperfusion and remodeling after injury in zebrafish models. The award funds investigation into how delayed vascular reperfusion contributes to chronic, non-healing wounds affecting approximately two percent of the U.S. population. The research examines molecular mechanisms...
- The National Heart, Lung, and Blood Institute awarded Harvard Pilgrim Health Care, Inc. Office of Sponsored Programs $571,839 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, R01HL183379) to investigate how early-life exposure to environmental toxicants influences cardiovascular health trajectories in children and adolescents. The research leverages data from 1,332 mother-child pairs enrolled in Project Viva, a prospective pre-birth cohort in eastern...
The National Heart, Lung, and Blood Institute awarded the University of Pittsburgh $758,972 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, Project Grant R01HL187185) to investigate overlooked socioeconomic determinants of adolescent cardiovascular health, specifically examining how family wealth, assets, and debts influence cardiovascular risk factors in youth. The research addresses the gap in existing scholarship by focusing on wealth as an economic resource distinct from and more unevenly distributed than income. The project will examine how parental assets enable investments in neighborhood selection, consumption smoothing after economic crises, positive future expectations, and financial safety nets, while analyzing how high debt levels force reductions in activities and expenses critical to adolescent cardiovascular health such as medical appointments and nutritious food. The work builds on evidence that cardiovascular disease pathophysiology unfolds over decades including adolescence, when measurable differences in physiological risk factors such as obesity and dyslipidemia, and behavioral factors such as insufficient sleep and physical activity, emerge as predictive of adult cardiovascular disease. The award supports prevention efforts aimed particularly at youth from lower-income households who may face elevated cardiovascular health risk. Performance occurs in Pittsburgh, Pennsylvania. The period of performance runs through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $759.0k | 8/15/26 |