Project Grant R01HL179090
- This Project Grant award, titled "Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes," is funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) for $169,020. The research aims to investigate the molecular mechanisms behind how cardiomyocytes (heart muscle cells) convert external mechanical signals into biochemical responses, particularly in relation to cellular adaptation and...
- The federal Project Grant award of $726,452 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to model intra- and inter-cellular networks involved in TRPC6-dependent cardiac fibrosis. The award aims to leverage computational methods and multi-scale experiments to better understand how TRPC6 signaling drives myofibroblast transformation and fibrosis in response to cardiac and dermal wounds. The research will be conducted by the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $194,375 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of California, Santa Barbara (UCSB) to study the impact of cardiomyopathy-driven extracellular matrix (ECM) remodeling on myocardial viscoelasticity and its effects on cardiomyocyte phenotype. The 24-month project aims to: 1) Determine how cardiomyopathy alters myocardial viscoelasticity, and 2) Assess how matrix viscoelasticity regulates...
- The Texas A&M University System Health Science Center received a $542,663 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the mechanistic role of small Rho GTPase in chronic cardiac fibrotic remodeling. The research aims to explore the dynamic function of fibroblast RhoE in post-myocardial infarction cardiac remodeling, with the goal of selectively mitigating prolonged fibrosis without interrupting...
- This $1,137,498.00 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to investigate the regulatory mechanisms involved in cardiac maturation. The primary awardee, The Trustees of the University of Pennsylvania, will conduct this work between April 1, 2025 and March 31, 2032. The research aims to address three key questions: 1) whether naturally-occurring variants in human cardiomyocyte genomic...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate how signaling pathways regulate cardiac progenitor cell proliferation and lineage specification during prenatal heart development. The $439,065 award to Swarthmore College will fund a 3-year project leveraging the simplified cellular model of the marine invertebrate Ciona robusta to decipher conserved mechanisms of signal-dependent...
- This $639,822 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to determine the role of neutral sphingomyelinase (nSMase), a membrane enzyme involved in lipid signaling, in the mechanical regulation of the heart. The research aims to investigate how nSMase contributes to normal cardiac function under acute changes in load, as well as its role in the deterioration of cardiac function during chronic overload...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This $385,381 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of dynamic biological hydrogels to modulate cardiac remodeling following myocardial infarction. The primary goals are to: 1) Improve the mechanical stability and stiffness of cardiac extracellular matrix hydrogels compared to existing therapies, and 2) Leverage changes in extracellular matrix composition to promote a more regenerative...
This federal Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the role of VCAN-GPR126 signaling in regulating cardiac growth and remodeling in response to mechanical forces. The $744,692 award to the University of Pennsylvania will fund research to test the hypothesis that VCAN, a proteoglycan, activates the mechanosensing adhesion G protein-coupled receptor GPR126 and that this signaling pathway is essential for normal cardiac development and pathologic cardiac remodeling. The research will utilize newly developed conditional and mutant mouse models to elucidate the mechanisms by which this VCAN-GPR126 signaling axis responds to mechanical cues in the heart. Findings from this work could help identify novel therapeutic targets for acquired heart diseases associated with abnormal cardiac remodeling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/22/25 | ||
| Not listed | $744.7k | 8/14/25 |