Project Grant R01HL185055
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $694,252 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for June 30, 2030. The award funds research into the mechanisms of cardioprotective Y RNA (YRNA) signaling in macrophages to enhance therapeutic outcomes following myocardial infarction. The research focuses on understanding how a...
- Federal Grant Award Summary Award Details: Cedars-Sinai Medical Center received a $1,214,851 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 20, 2025, with completion targeted for May 31, 2029. Research Scope and Deliverables: The grant funds investigation of nuclear transport mechanisms for SMAD signaling proteins, which are critical developmental effectors in left-right axis formation...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Cedars-Sinai Medical Center a Project Grant totaling $497,998 beginning September 1, 2025, and concluding August 31, 2028, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds basic research investigating the nature and regulation of extramedullary hematopoiesis (EMH) in the liver, with focus on understanding how hematopoietic stem cells (HSCs) initiate blood cell production...
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $717,680 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for March 31, 2029. The grant funds research to elucidate the immune epithelial niche underlying post-viral lung fibrosis, specifically investigating how persistent pulmonary fibrosis develops following severe viral respiratory...
- Project Grant Award Summary Cedars-Sinai Medical Center received a $740.5K Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 6, 2026, with completion targeted for March 31, 2030. The project focuses on advancing single-cell proteomics (SCP) technology to characterize protein heterogeneity in cardiomyocytes (CMs) affected by hypertrophic cardiomyopathy (HCM) mutations associated with the myosin...
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $256,650 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 2, 2026, with a completion date of June 30, 2028. The project, titled "ISG15 Monocytes as Precursors to SPP1 Macrophages in Scleroderma ILD," will deliver mechanistic research and biomarker discovery services focused on...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $757,555 Project Grant award dated September 5, 2025, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate advanced magnetic resonance imaging (MRI) technology for quantifying iron content in hemorrhagic myocardial infarction (HMI) hearts. The project, which extends through June 30, 2029, addresses a critical clinical need by creating a...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $739,474 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 18, 2025, to investigate the anti-fibrotic roles of stress-induced tRNA-derived small RNAs (tDRs) in cardiac fibrosis. The research will be conducted through May 31, 2030, and focuses on characterizing the mechanisms by which ASP-GTC-3' tDR, a regulatory RNA fragment derived from transfer RNA,...
- Federal Grant Award Summary Yale University received a $1.498 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 23, 2025, with a completion date of August 31, 2027. The award funds research investigating the molecular mechanisms of sex differences in scleroderma-associated interstitial lung disease (SSc-ILD), specifically examining the role of mitochondrial DNA (mtDNA) and Toll-like...
Award Overview
Cedars-Sinai Medical Center received a $300,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Trans-NIH Research Support program (CFDA 93.310) effective July 8, 2026, with a completion date of April 30, 2031. This award supports therapeutic preclinical development of TY1, a novel synthetic noncoding RNA (ncRNA) drug candidate designed to treat scleroderma-associated systemic sclerosis (SSC) cardiomyopathy. Products and Services Delivered
The funded research will generate preclinical scientific evidence and mechanistic data regarding TY1's cardioprotective efficacy in reversing cardiac fibrosis and improving diastolic function in models of SSC. Deliverables include investigations into TY1's mechanism of action (upregulation of the DNA exonuclease TREX1 and attenuation of the innate immunity cGAS/STING pathway), validation of its antifibrotic effects in bleomycin and genetic (TSK-1) mouse models of scleroderma, characterization of macrophage-mediated pathways underlying therapeutic benefit, and optimization of oral formulation delivery using casein/chitosan micelle technology. The research will establish the scientific foundation necessary to advance TY1 toward clinical development for a disease with limited effective therapeutic options.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 7/9/26 |