Project Grant R00HL173841
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the regulation of extramedullary hematopoiesis (EMH) in the liver. The $260,674 award to the Trustees of Columbia University in New York City, New York, with a performance period of January 1, 2025 to August 31, 2025, will fund three specific aims: 1) characterizing the cellular components of the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This $147,486 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Southern California to investigate the heterogeneous intercellular signaling of hematopoietic stem and progenitor cells (HSPCs) and its changes around the circadian clock. The research aims to advance understanding of how HSPC cell-cell communication and gene expression patterns within the bone marrow microenvironment are...
- The federal Project Grant award titled "NICHE-SPECIFIC ENDOTHELIAL MECHANISMS REGULATING THE EXTRAVASATION OF HEMATOPOIETIC STEM CELLS" is funded by the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837). The $734,607 award, effective May 1, 2025 through February 28, 2030, supports research at Boston Medical Center Corporation to elucidate the key endothelial mechanisms that direct circulating hematopoietic stem cells across the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $536,468 to the University of California, San Diego (UC San Diego) to conduct research on protein aggregation in hematopoietic stem cells (HSCs). The project aims to investigate how HSCs, which regenerate blood and immune cells, preferentially traffic misfolded proteins to aggresomes to maintain fitness and self-renewal, and how this process is impacted by...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $776,511 to the Fred Hutchinson Cancer Center (Seattle, WA) to develop a 3D engineered hemogenic vascular niche model that supports the induction of hematopoietic fates from human pluripotent stem cell-derived endothelium. The primary objective is to leverage this innovative platform to investigate how intrinsic arterial...
- This $240,552 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research project titled "Unraveling the Cell Networks in Bone Marrow Through Transcriptomic and Epigenetic Profiling" at the University of Pennsylvania. The project aims to generate a comprehensive single-cell transcriptomic and regulomic map of human bone marrow cells and experimentally establish the mesenchymal cell hierarchy in human bone....
- This $153,117 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the recipient's independent research career as an academic hematopathology physician-scientist. The key objectives are to study hematopoietic stem and progenitor cell (HSPC) crosstalk and transplantation, with the overarching goal of improving HSPC transplantation outcomes. The award period runs from August 1, 2025 to July 31,...
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Cedars-Sinai Medical Center in West Hollywood, CA provides $248,999.00 in funding from September 1, 2025 through August 31, 2028. The project aims to characterize the cellular components of the hematopoietic stem cell (HSC) niche in the liver during extramedullary hematopoiesis, identify HSC clones initiating liver extramedullary hematopoiesis, and investigate the role of the HSC-autonomous splicing regulator RBFOX2 in regulating liver extramedullary hematopoiesis formation. This research seeks to advance the understanding of how intrinsic and extrinsic factors regulate HSC function and the interplay between HSC biology and immunology, with the goal of improving treatments for immunity-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/15/25 |