Project Grant R01HL184914
- The National Heart Lung and Blood Institute awarded The Regents of the University of California, San Francisco $1,265,657 on September 20, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a two-stage randomized trial evaluating optimal tuberculosis screening and preventive therapy delivery strategies for pregnant women with HIV in Uganda. The study uses a sequential, multiple assignment, randomized trial design to determine whether C-reactive protein screening...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of California, San Francisco $358,032 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a systematic evaluation of post-tuberculosis lung disease (PTLD) and its relationship to HIV status. The project, titled "The Sequelae TB Study," will comprehensively characterize PTLD among a prospective cohort of TB survivors in Lusaka, Zambia. The...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $842,888 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify immunological and transcriptional factors associated with treatment outcomes in drug-susceptible tuberculosis. The recipient will conduct transcriptional profiling of whole blood to define pathways and genetic regulatory networks associated with shorter time...
- The National Institute of Allergy and Infectious Diseases awarded Brigham & Women's Hospital $685,682 on September 23, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the use of chest radiography in detecting early tuberculosis in children and youth. The research evaluates whether chest radiography abnormalities identified during community-based TB screening can predict subsequent active TB disease in young individuals, with the goal of...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $4.760584 million on September 23, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct the Rapid Research for Diagnostics Development in TB Network: Episode 2 (R2D2 TB Network II). UCSF will solicit, review, and prioritize novel tuberculosis diagnostics across different phases of development and use cases for evaluation. The work...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $200,880 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop integrated host-microbe metagenomic sequencing methods for diagnosing and predicting complications in lung transplant recipients. The project will develop metagenomic classifiers from bronchoalveolar lavage fluid to more accurately diagnose lower respiratory tract infection in...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $778,504 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate molecular mechanisms controlling lung capillary speciation, plasticity, and function during early postnatal development. The research examines how distinct subtypes of lung capillary endothelial cells—CAP1 and CAP2—contribute to alveolar formation and repair after injury during...
- The National Heart, Lung, and Blood Institute awarded Trustees of Boston University (doing business as Boston University Medical Campus) $837,000 in project grant funding on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into lung-specific mechanisms that enable Mycobacterium tuberculosis survival and progression in immunocompetent hosts. The project examines how dysplastic epithelial cells within pulmonary tuberculosis lesions...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $463,601 to The Regents of the University of California, San Francisco on June 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research investigating how cytomegalovirus (CMV) infection compromises immune control of Mycobacterium tuberculosis (MTB), the pathogen causing tuberculosis. The research employs a murine co-infection...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded Emory University $123,654 on August 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct mentoring in patient-oriented translational research on tuberculosis, HIV, and lung health (Project Grant K24HL189236). The award funds research to identify risk factors for post-TB lung disease (PTLD) and develop evidence-based interventions to prevent PTLD and improve long-term respiratory health among TB...
The National Heart Lung and Blood Institute, under the Department of Health and Human Services, awarded $369,089 to The Regents of the University of California, San Francisco on September 1, 2026, through the Cardiovascular Diseases Research program (CFDA 93.837). The recipient is developing and evaluating computer-aided detection algorithms to support screening, diagnosis, and treatment of tuberculosis in children with and without HIV. The project addresses gaps in pediatric TB diagnosis, where chest X-ray interpretation remains a major barrier to accurate case identification. The work will fine-tune existing artificial intelligence models trained on adult TB data using large, well-characterized repositories of pediatric chest X-ray images and clinical data. Deliverables include validated algorithms to support TB diagnosis and severity stratification in children, filling a gap where no approved automated solution currently exists for the pediatric population. UCSF's Controller's Office serves as the awardee. Work is performed in Oakland, California. The period of performance runs through May 31, 2030. This is a Project Grant, classified as assistance funding. The award leverages UCSF's existing partnerships with computer-aided detection developers and deep learning expertise alongside its established clinical data repositories and pediatric TB diagnostic experience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $369.1k | 8/27/26 |