Project Grant R01HL188253
- The National Heart, Lung, and Blood Institute awarded Northwestern University $684,570 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate a bioengineered mitochondrial therapy platform for endothelial repair in vascular surgery. The research addresses endothelial injury, a fundamental barrier in vascular procedures that contributes to post-operative complications including vein graft failure, restenosis, and thrombosis. Northwestern's...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,597,024 under the Cardiovascular Diseases Research program (CFDA 93.837) on July 1, 2026, to investigate mitochondrial quality control mechanisms in donor heart endothelial and smooth muscle cells as a strategy to improve cardiac allograft survival and reduce cardiac allograft vasculopathy following heart transplantation. The research addresses the acute and chronic phases of transplant injury:...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $225,156 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of vasa vasorum angiogenesis in tissue-engineered vascular grafts (TEVGs) resistant to calcification. The research develops matrix metalloprotease-degradable polyethylene glycol hydrogels (MMP-PEG) to coat the adventitial surface of decellularized aortas, enabling manipulation of TEVG adventitia...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $2,162,045 under Cardiovascular Diseases Research (CFDA 93.837) on September 15, 2025, for research characterizing apolipoprotein proteoforms and their relationships with cardiometabolic health and coronary heart disease events. The research objective is to characterize the full spectrum of apolipoprotein post-translational modifications in human plasma and to quantify their associations with adiposity, insulin...
- The National Heart, Lung, and Blood Institute awarded Northwestern University a project grant of $793,976 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate bone morphogenetic protein and connexin40 signaling as regulators of endothelial quiescence in lung transplantation. The research addresses primary graft dysfunction, an acute lung injury driven by ischemia-reperfusion injury that limits lung transplantation success. The project will...
- The National Heart Lung and Blood Institute awarded the Beckman Research Institute of the City of Hope $813,810 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on nucleotide supplementation as a treatment strategy for ischemic heart disease and myocardial infarction. The project investigates the role of nucleotide balance in cardiomyocyte proliferation and aims to apply these findings for cardiac repair using large animal models....
- The National Heart, Lung, and Blood Institute awarded Northwestern University $1,589,058 under the Cardiovascular Diseases Research program (CFDA 93.837) on June 25, 2026, to support research on disordered mitochondrial proteostasis and alveolar epithelial repair in aging lungs. The project investigates how age-related dysfunction in mitochondrial complex I impairs lung recovery following viral pneumonia, with a focus on the role of alveolar epithelial type 2 cells in epithelial repair and the...
- The National Heart, Lung, and Blood Institute awarded New York University $872,787 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct proteomic discovery and validation research on chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease. The award funds development of proteomic signatures to predict major adverse limb events (MALE) and major adverse cardiovascular events (MACE) in CLTI patients, and to guide...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $696,259 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop flexible electronics and optogenetics approaches for real-time arrhythmic profiling of engineered heart tissues. The project runs through April 30, 2031, with work performed in Chicago, Illinois. The award funds development of non-invasive arrhythmia assessment methods for human induced pluripotent stem cell–derived...
- The National Heart Lung and Blood Institute awarded Northwestern University $2,139,171 under Project Grant R01HL184083 on September 1, 2026, to conduct epidemiological and mechanistic research linking ectopic fat with inflammation and atherosclerosis. The research addresses gaps in understanding how distinct fat depots—hepatic, visceral, epicardial, and pericoronary—drive local vascular inflammation and coronary plaque formation across populations. Northwestern will leverage two...
The National Heart, Lung, and Blood Institute awarded Northwestern University $812,196 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2026, to conduct research on targeted NAD+ replenishment as pre- and post-bypass therapy against vein graft failure. The research addresses the clinical problem that up to 20 percent of vein grafts fail within the first year following bypass surgery, and nearly half are occluded by 10 years. The award funds investigation of nicotinamide adenine dinucleotide (NAD+) depletion as a potential driver of vein graft failure and testing of nanoparticle-based NAD+ delivery systems to preserve endothelial cell health and limit intimal hyperplasia. The study includes two aims: evaluation of NAD+ repletion in modulating acute endothelial dysfunction caused by intraoperative storage, and assessment of systemic post-bypass delivery of platelet membrane-coated NAD+-nanoparticles to target vein grafts and limit hyperplasia. Work is performed at Northwestern University in Chicago, Illinois, with a period of performance through May 31, 2030. This is a project grant, the standard assistance type for research awards under the program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $812.2k | 8/14/26 |