Project Grant R01HL183579
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funded under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,098,640 grant, awarded on September 18, 2025, supports a longitudinal research project titled "Modeling Inter-Individual Differences to Address Pain of Sickle Cell Disease (MIDAS)" at the University of Texas at Arlington (UTA). The project aims to collect...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance the understanding of the molecular and neurobiological mechanisms underlying chronic pain in sickle cell disease (SCD) and develop effective pharmacologic treatments. The $1,103,783 award to the University of Illinois will utilize well-characterized sickle cell transgenic mouse models to study epigenetic, neurobiology, and gut microbiota...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,764,145.00 to Midwestern University to conduct research on miRNA as a novel therapeutic target for pain management in sickle cell disease (SCD). The long-term goal is to develop effective pharmacological interventions to alleviate chronic pain and improve quality of life for SCD patients. The research focuses on...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a $1,955,201 Cooperative Agreement to Cincinnati Children's Hospital Medical Center under the NIH Drug Use and Addiction Research Programs (CFDA 93.279). The 5-year award, effective September 19, 2025 through July 31, 2030, will support research to better understand the biopsychosocial determinants of pediatric-onset chronic musculoskeletal pain. The research will...
- This $4,039,366 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), will support a research project titled "A Fully Humanized Functional Genomic Screen to Identify and Validate Pain Therapeutic Targets" under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279). The project will leverage innovative CRISPR-based screening and human dorsal root ganglion (DRG) transcriptomic data to...
- This $147,486 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Carnegie Mellon University supports research to identify and target neural subpopulations in the spinal cord that mediate chronic pain. The project aims to analyze the genomic cis-regulatory elements (CREs) of neural subtypes in the macaque and mouse spinal cord to characterize the genetic markers...
- This federal Project Grant award of $118,457.00 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), is funded under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research by Dr. Sylvanus Toikumo at the University of Pennsylvania to characterize the genetic architecture underlying chronic pain and addiction, with the goal of informing the development of non-addictive analgesic medications. The project aims to leverage...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $122,840 project grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Medical College of Wisconsin (MCW) to support "Patient-Oriented Research Mentoring for the Investigation of Acute and Chronic Sickle Cell Disease Pain". The goal of this 5-year grant, awarded on August 1, 2025, is for Dr. Amanda Brandow, a mid-career physician-scientist, to enhance her mentoring skills and develop the next...
This $1,049,682 federal Project Grant award from the National Institute of Neurological Disorders and Stroke, under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a 5-year prospective cohort study to develop and validate novel computational and clinical tools for understanding and addressing differences in pain experience and response to pain treatment among people with sickle cell disease (SCD). The study will utilize the Globin Research Network for Data and Discovery (GRNDAD) multi-site SCD registry to obtain representative measurements across 7 key domains impacting acute and chronic SCD pain in 1,250 individuals aged 15 and older living with SCD in the U.S. The goal is to improve pain assessment and management for SCD patients by better understanding the acute to chronic pain spectrum, how pain experiences evolve over time, and how individual factors affect pain state.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/17/25 |