Project Grant R01HL181155
- This federal Project Grant award of $133,221 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to investigate mechanisms underlying chronic inflammatory airway diseases such as chronic rhinosinusitis and asthma. The research aims to develop computational approaches to inform new treatment and prevention strategies for these prevalent, costly conditions....
- This federal Project Grant award for $490,075.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The grant supports research to investigate the role of vitamin D metabolites in modulating inflammation associated with chronic rhinosinusitis (CRS)-related olfactory loss. The key objectives are to 1) dissect the interplay between olfactory loss, vitamin D...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $702,308 project grant to the University of Colorado-Denver for a study titled "Function and Regulation of Airway Mucin Glycosylation". The project, with a performance period from September 1, 2025 to June 30, 2029, aims to investigate the role of mucin glycosylation, specifically the enzyme fucosyltransferase 2 (FUT2), in regulating mucus...
- This $387,116 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of South Florida to investigate the sensory neuronal mechanisms underlying the development of house dust mite-induced airway hyperreactivity, a key characteristic of asthma. The long-term goal is to define the neural mechanisms triggered by house dust mite exposure that lead to the development of airway...
- This Project Grant award for $185,866.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to modulate airway epithelial syndecan-1 in a preclinical model of steroid-resistant asthma. The research aims to examine the role of syndecan-1 and its cleavage by the enzyme heparanase in driving inflammation and glucocorticoid resistance in severe allergic asthma. The study...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund research to investigate the impact of glycocalyx degradation on the pathogenesis and outcomes of Acute Respiratory Distress Syndrome (ARDS). The award of $188,740 to the University of Pittsburgh aims to establish a framework for translating discoveries about the role of the pulmonary endothelial and epithelial glycocalyces in ARDS into...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $511,578 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on August 21, 2025, will fund research to understand the role of bitter taste receptors (T2Rs) in oral cancer tumor-associated macrophages. The research aims to define the...
- This $1,392,946 Project Grant awarded on July 20, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of Pittsburgh to investigate the role of microbial-derived metabolites in driving airway hyperresponsiveness in obesity-associated asthma. The project aims to elucidate how dysregulated bile acid metabolism and gut dysbiosis instigate obesity-related asthma through alterations in the unfolded protein...
- This $2,456,717 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to exploit emerging ideas in G protein-coupled receptor biology and pharmacology to treat asthma. The award supports a highly collaborative research team at Thomas Jefferson University's Sidney Kimmel Medical College to pursue three key goals: 1) identify novel targets and targeting molecules involving G protein-coupled receptor...
This federal Project Grant award of $506,420.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to elucidate the role of sweet taste receptors (T1R) in regulating airway glucose levels and their impact on inflammatory airway diseases like chronic rhinosinusitis (CRS). The primary objectives are to define the T1R signaling pathways in human nasal ciliated cells and assess the relationship between T1R polymorphisms, airway surface liquid glucose levels, and CRS patient outcomes. The award period is from September 1, 2025 to May 31, 2029, and the research will be conducted by the University of Pennsylvania. The findings may lead to the development of new therapeutic approaches that utilize sugar analogues or artificial sweeteners to enhance local innate immunity by lowering airway surface glucose and limiting respiratory infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.4k | 8/18/25 |