Project Grant R01HL181110
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,401,048 for Project Grant R01HL184086 on September 1, 2026 under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds GO MOMS PREDICT, a prospective study that develops and tests pregnancy-based cardiovascular disease risk assessment models to predict cardiovascular outcomes five years after delivery. The study leverages an existing...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $169,348 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research applying partitioned polygenic risk scoring and machine learning-derived imaging phenotypes to discover novel mechanisms of cardiometabolic disease in people of South Asian ancestry. Dr. Bhattacharya will develop unbiased SNP-level and gene...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $249,000 under the Cardiovascular Diseases Research program (CFDA 93.837) on April 1, 2026, for whole genome sequence interpretation to identify new genes and mechanisms underlying coronary artery disease and familial hypercholesterolemia. The award funds research to improve genetic diagnostic yield for familial hypercholesterolemia, an inherited form of...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (Massachusetts General Hospital) $3,330,084 under the Cardiovascular Diseases Research program (CFDA 93.837) on August 10, 2026, for a project grant investigating causal links between the maternal plasma proteome, preeclampsia, and future cardiovascular disease. The research leverages proteomic analysis of circulating microparticles isolated from maternal plasma samples collected across first, second, and...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $614,843 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research examining the relationship between indexed exercise blood pressure and adverse vascular and ventricular remodeling as risk factors for heart failure with preserved ejection fraction (HFPEF). The research investigates whether the ratio of peak...
- The National Institutes of Health National Heart Lung and Blood Institute awarded The General Hospital Corporation (Massachusetts General Hospital) $186,840 under CFDA 93.837 Cardiovascular Diseases Research on July 3, 2026, for advanced analysis of high-resolution cardiac diffusion tensor imaging (DTI). The funded work develops and applies DTI phenomapping, a voxel-level quantitative analysis approach for cardiac magnetic resonance imaging that resolves distinct microstructural patterns in...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. $249,000 on March 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct genomic and functional molecular analyses investigating the mechanistic links between clonal hematopoiesis of indeterminate potential (CHIP) and coronary artery disease (CAD). The recipient will discover further germline genetic predisposition that induces CHIP-related cardiovascular disease using an...
- The National Heart, Lung, and Blood Institute awarded Massachusetts General Hospital (The General Hospital Corporation) $185,196 on January 7, 2027 under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds a pilot multi-center cohort study examining patient and caregiver burden in chronic limb-threatening ischemia (CLTI). Aim 1 will assess how caregiver support relates to patient outcomes including quality of life, amputation, readmission, and mortality, collecting...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $170,432 under Project Grant K08HL183784 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). Dr. Urbut will develop and validate a novel Bayesian multivariate model integrating time-varying genetic and clinical factors across over 300 diagnostic phenotypes to identify latent disease signatures for genomic discovery and produce...
- The National Heart, Lung, and Blood Institute awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $736,411 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of neutrophil-derived resistin-like molecule G (RELMG) in arrhythmia pathogenesis and prevention. The research examines RELMG's mechanism of action and therapeutic potential in reducing ventricular tachycardia and atrial fibrillation following...
The National Heart, Lung, and Blood Institute (NHLBI) awarded the Massachusetts General Hospital's Research Management Division $842,536 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the mechanisms linking gestational diabetes mellitus (GDM) to increased coronary artery disease risk in women. The research integrates longitudinal electronic health records data spanning approximately 30 years postpartum for more than 208,000 women with GDM history, combined with multi-omics analysis of more than 5,400 plasma proteins, Nightingale metabolomics panels, and genetic data. The study examines two distinct causal pathways linking GDM to future cardiovascular disease: type 2 diabetes-mediated pathways (such as insulin resistance) and type 2 diabetes-independent pathways (such as lipid metabolism alterations). The analysis will establish time-series trajectories of cardiovascular risk and their contributions to coronary artery disease onset, addressing a gap in current clinical practice that focuses on type 2 diabetes screening for women with prior GDM while omitting cardiovascular disease prevention strategies. Performance takes place in Boston, Massachusetts. The award period runs from August 1, 2026 through April 30, 2031. This is a Project Grant, the standard assistance type for investigator-initiated NIH research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $842.5k | 8/4/26 |