Project Grant R01HL185119
- Federal Project Grant Award Summary Massachusetts General Hospital's Research Management Division received a $867,656 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on May 1, 2026, with a completion date of February 28, 2031. The award funds research to determine the effectiveness of guideline-directed medical therapies (GDMT) for heart failure with mildly reduced ejection fraction (HFmrEF)—a...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $739,474 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 18, 2025, to investigate the anti-fibrotic roles of stress-induced tRNA-derived small RNAs (tDRs) in cardiac fibrosis. The research will be conducted through May 31, 2030, and focuses on characterizing the mechanisms by which ASP-GTC-3' tDR, a regulatory RNA fragment derived from transfer RNA,...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $1,519,316 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2029. The award funds development and clinical validation of mechanomicroscopy, an innovative endoscopic imaging platform designed to enable transbronchial assessment of pulmonary hypertension (PH)...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $247,500 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 1, 2025 through August 31, 2027. The award supports research to develop a non-invasive biomarker-based classifier model for early detection of pulmonary vascular dysfunction (PVD) in acute respiratory distress syndrome (ARDS) patients. ARDS patients with PVD...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Harvard College's Office for Sponsored Programs a Project Grant of $151,040 on February 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The research will be conducted in Massachusetts and is expected to conclude by November 30, 2028. This award funds investigative research into the role of Tolloid (TLD) proteases in atrial fibrosis pathogenesis, specifically examining how TLD...
- Federal Grant Award Summary Massachusetts General Hospital received a $761,615 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 21, 2025, with a completion date of June 30, 2030. The grant supports translational and clinical research investigating alveolar epithelial glycocalyx resilience in women experiencing Acute Respiratory Distress Syndrome (ARDS). The research addresses the mechanistic...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts Institute of Technology $1.48 million under the Cardiovascular Diseases Research program (CFDA 93.837) to develop advanced analytical and machine learning methodologies for evaluating treatment strategies in acute respiratory distress syndrome (ARDS). The grant, awarded September 23, 2025, with completion targeted for August 31, 2027, will deliver research products addressing...
- Federal Project Grant Award Summary Boston University Medical Campus received a $122,625 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) beginning June 1, 2025 and concluding May 31, 2027. The award funds research and development of novel small molecule therapeutics targeting oxidized sirtuin-1 (SIRT1) as a potential treatment for aortic aneurysms in Marfan Syndrome. The research deliverables...
- Federal Project Grant Award Summary Award Details: Massachusetts General Hospital's Research Management Division received $194,080 in federal funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award was obligated on February 15, 2026, with an ultimate completion date of August 17, 2027. Products and Services: This Project Grant supports health services research utilizing mixed methods to optimize the...
- Federal Project Grant Award Summary Massachusetts General Hospital's Research Management Division received $186,840 in federal funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for a project titled "Advanced Analysis of High-Resolution Cardiac Diffusion Tensor Images." The award was obligated on July 3, 2026, with a completion date of June 30, 2031. The research deliverables focus on advancing diffusion...
Massachusetts General Hospital's Research Management Division received a $736,411 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with a completion date of March 31, 2031. The award funds investigative research into the role of neutrophil-derived resistin-like molecule G (RELMG) in cardiac arrhythmias, specifically ventricular tachycardia (VT) and atrial fibrillation (AFib) occurring following myocardial infarction (MI) and ischemic cardiomyopathy. The research aims to elucidate RELMG's mechanism of action and determine the therapeutic potential of inhibiting this molecule as a novel treatment strategy to reduce life-threatening arrhythmias after acute and subacute MI events. The deliverables include mechanistic studies examining how RELMG—a member of the resistin protein family secreted by innate immune cells—interacts with ischemic cardiomyocytes, hypothesis-driven preclinical research using established MI-VT models to validate therapeutic targeting of RELMG in both acute (24-hour) and subacute (30-day) post-MI intervals, and exploratory investigation of RELMG's role in AFib pathogenesis. The research leverages preliminary findings demonstrating a twelvefold reduction in VT when RELMG is deleted in bone marrow cells and seeks to translate these findings into potential clinical therapeutics addressing the limited efficacy and significant side effects of current arrhythmia treatment options.Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $736.4k | 7/8/26 |