Project Grant R01HL181091
- This Project Grant award, valued at $507,718.03 and awarded on December 9, 2024, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Cedars-Sinai Medical Center to conduct research on "Non-Contrast 3D T1ρ Mapping for Myocardial Fibrosis Quantification of Pediatric Cardiomyopathy Patients." The research aims to develop a non-contrast cardiac MRI technique that can accurately detect and quantify myocardial fibrosis in pediatric...
- This $834,249 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a comparative study of clinical outcomes, patient experiences, and mechanistic insights between transcatheter and surgical treatment of degenerative mitral regurgitation (DMR). The study aims to provide long-term data on clinical effectiveness, safety, and patient-reported outcomes to inform treatment selection and guide patient care. It will also utilize...
- This Project Grant award of $1,526,628.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Cedars-Sinai Medical Center to develop Artificial Intelligence (AI) methods for analyzing echocardiography data to predict biological cardiovascular age and identify trajectories of accelerated versus delayed cardiovascular aging. The research aims to capture an aggregate measure of cardiac aging and identify potential interventions to...
- This $702,534 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Texas A&M Engineering Experiment Station (Tees) to develop an integrated super-resolution cardiac magnetic resonance imaging-deep learning (CMR-DL) technology. The goal is to isolate and quantify the contributions of passive and active mechanisms to impaired left ventricular relaxation, a key driver of left ventricular diastolic dysfunction...
- The federal Project Grant award of $507,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure electrophysiological properties and contractile forces in single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This innovative system is expected to significantly reduce measurement time...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $783,801 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The grant, titled "Demonstrating the Feasibility of Democratized Push-Button Autonomous Cardiac MRI Exam in Community Family Health Centers (AutoCMR for FHC)", aims to demonstrate the feasibility of using a push-button, time-resolved 3D...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Cedars-Sinai Medical Center in West Hollywood, CA provides $248,999.00 in funding from September 1, 2025 through August 31, 2028. The project aims to characterize the cellular components of the hematopoietic stem cell (HSC) niche in the liver during extramedullary hematopoiesis, identify HSC clones initiating liver extramedullary hematopoiesis, and investigate the role of...
- The University of Utah was awarded a $756,947 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on March 10, 2025. The project aims to improve and better understand the factors that influence spin-locking cardiac MRI for assessing myocardial fibrosis, a key indicator of cardiovascular disease. The key objectives are to: 1) study the value of different T1rho MRI methods and conventional techniques in preclinical models of diffuse and...
- This Project Grant award of $784,362.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Brigham & Women's Hospital Inc., will support research investigating the role of body composition, coronary microvascular dysfunction, and heart failure with preserved ejection fraction in characterizing adverse cardiometabolic disease phenotypes. The research aims to leverage novel imaging technologies to identify mechanisms of...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $694,252.00 to Cedars-Sinai Medical Center in California to investigate the mechanisms of cardioprotective Y RNA signaling in macrophages. The goal is to better understand how a small non-coding RNA called YREX3 can enhance the ability of macrophages to clear dead cells and promote cardiac tissue healing after a myocardial...
This Project Grant award for $757,555 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Cedars-Sinai Medical Center to develop and validate a multi-orientation quantitative susceptibility mapping (QSM) MRI technique. The goal is to accurately quantify iron content in the hearts of patients who have experienced hemorrhagic myocardial infarction, which can lead to complications like congestive heart failure. The project aims to overcome technical limitations of current cardiac iron imaging methods to enable improved monitoring of iron levels and facilitate individualized treatment plans. This 4-year research effort, with a start date of September 5, 2025 and an ultimate completion date of June 30, 2029, seeks to advance the clinical utility of QSM for assessing iron-related cardiac damage following acute myocardial infarction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $757.6k | 9/4/25 |