This Project Grant award of $756,947 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to improve the assessment of myocardial fibrosis using spin-locked MRI techniques. The key objectives are to:
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Study the efficacy of different T1rho MRI methods and conventional MRI techniques in preclinical models with either diffuse or focal myocardial fibrosis.
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Develop and validate new combined multi-parametric cardiac MRI methods to quantitatively measure myocardial fibrosis without using gadolinium contrast.
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Characterize the repeatability of the T1rho and other MRI methods in patients with cardiac disease, and evaluate the ability of the new gadolinium-free techniques to predict extracellular volume maps.
This research seeks to advance the diagnosis and evaluation of therapies for myocardial fibrosis, a key contributor to cardiovascular disease and disability. The project runs from March 2025 through December 2028 and is being conducted by the University of Utah.
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