Project Grant R01HL180504
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $742,395 to Case Western Reserve University (CWRU) to develop and validate a machine learning-based analysis of coronary artery calcium scans (CTCS) to identify biomarkers for predicting heart failure risk. The 4-year project aims to create an automated tool for extracting CTCS-derived radiomics, develop a comprehensive heart failure risk...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $429,153 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Michigan Technological University. The funding supports research to improve patient selection and left ventricular lead placement for cardiac resynchronization therapy (CRT) by integrating analysis of electrical dyssynchrony on ECG and mechanical dyssynchrony on gated SPECT myocardial perfusion imaging. The project aims to use unsupervised...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $294,023 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to Heartlung Corporation to develop the AUTOCHAMBER AI tool. AUTOCHAMBER is designed to opportunistically screen existing chest CT scans for early detection of enlarged cardiac chambers and left ventricular hypertrophy, which can indicate risk of atrial fibrillation, stroke, and heart failure. The project...
- The National Heart Lung and Blood Institute (NHLBI) awarded a $711,039 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Research Institute at Nationwide Children's Hospital. The award supports research to determine the functions of the cardiac m6A methyltransferases METTL3 and METTL14 in early myocardial development, and whether their dysregulation contributes to the pathogenesis of fetal dilated cardiomyopathy (DCM). The proposed study leverages mouse...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $730,764 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Case Western Reserve University (CWRU) to conduct research on the molecular basis for cardiac myosin binding protein C (cMyBP-C) variants that cause hypertrophic cardiomyopathy (HCM). The project aims to utilize cryo-electron microscopy and other techniques to define how cMyBP-C missense variants affect cardiac sarcomere structure and...
- This federal Project Grant award, with a total funding amount of $304,415.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The goal of this 1-year project is to develop a software solution that uses artificial intelligence and image analytics to improve cardiovascular risk prediction from screening CT calcium score (CTCS) images. The project team, which includes engineers and clinicians from...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $243,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati's Sponsored Research Services Division. The grant will fund a 2-year project to engineer advanced RNA biodevices that leverage CRISPR and ADAR gene-editing technologies. The goal is to improve the efficiency and specificity of converting resident cardiac fibroblasts into functional cardiomyocytes, in order to boost...
- The Project Grant award of $639,621 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) to investigate mitochondrial signaling between cardiomyocytes and fibroblasts, and its role in cardiac fibrosis. The research aims to determine how cardiomyocyte-derived mitochondria mediate crosstalk with cardiac fibroblasts, which may underlie the...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $443,544 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to Dasisimulations LLC, a minority-owned small business located in Dublin, Ohio. The grant supports the development and validation of an innovative, AI-driven software platform to automatically perform complex measurements for pre-planning transcatheter aortic valve replacement (TAVR) procedures. The project aims to (1) develop and validate the...
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $126,309 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Children's Hospital Medical Center in Cincinnati, Ohio. This 2-year research project, awarded on June 16, 2025, aims to characterize the functional role of a novel cardiac and adipose-enriched microprotein called NRAC and its involvement in lipid droplet biogenesis and lipid metabolism within the cardiovascular system. The research will...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $783,801 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The grant, titled "Demonstrating the Feasibility of Democratized Push-Button Autonomous Cardiac MRI Exam in Community Family Health Centers (AutoCMR for FHC)", aims to demonstrate the feasibility of using a push-button, time-resolved 3D cardiac MRI protocol and automated reporting (CMR-Target) to enable comprehensive cardiac imaging in underserved community family health centers. The project seeks to increase access to cardiac MRI for heart failure diagnosis, particularly in rural and urban minority populations. The grant period runs from September 3, 2025 to May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $783.8k | 9/3/25 |