Project Grant R01HL180619
- The National Heart, Lung, and Blood Institute (NHLBI), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical College of Wisconsin, Inc. $792,011 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to validate plasma cell-free DNA (CFDNA)—including nuclear and mitochondrial variants—as a clinically actionable biomarker for predicting critical post-surgical events in infants undergoing complex congenital heart surgery....
- The National Heart, Lung, and Blood Institute awarded Baylor College of Medicine $248,993 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop metasurface optical guidewires for treating coronary artery calcification during percutaneous coronary intervention. The award funds design and manufacture of sub-millimeter meta-surface optics for optical guidewires, development of optimized PCI workflows for laser-induced intravascular lithotripsy, and...
- The National Heart, Lung, and Blood Institute, part of the National Institutes of Health under the Department of Health and Human Services, awarded The Medical College of Wisconsin, Inc., $234,000 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The Medical College of Wisconsin will conduct a single-cell dissection of cellular and transcriptional dynamics driving post-transplant relapse in myelodysplastic syndromes (MDS). The research leverages longitudinal...
- The National Heart, Lung, and Blood Institute awarded The Medical College of Wisconsin, Inc. $198,728 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of the RNA-binding protein PABPC1 in endothelial gene expression and angiogenesis. The research addresses mechanisms of angiogenesis—the formation of new blood vessels from existing vasculature—using in vitro human cell culture models and in vivo mouse knockout studies. The project...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University $577,334 on July 9, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a sensory airway stent for continuous monitoring of airway conditions. The recipient is creating a sensor-integrated airway stent (SAS) equipped with flexible sensors and a wearable magnetic actuation unit designed to monitor stent patency and airway health in the central airway. The innovation addresses central airway...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $151,092 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through July 31, 2030. This five-year research initiative focuses on investigating macrophage polarization and function in graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation...
- The National Heart, Lung, and Blood Institute awarded Minnesota Healthsolutions Corporation $329,537 on August 15, 2026, to develop a novel balloon angioplasty inflation device under the Cardiovascular Diseases Research program (CFDA 93.837). The recipient will design and evaluate a prototype inflation device intended to improve safety and efficacy during percutaneous balloon angioplasty by accounting for molecular composition and elasticity differences in arterial tissue. Current market devices...
- The National Heart, Lung, and Blood Institute awarded the University of Wisconsin – Madison $521,101 on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of macrophages and hematopoietic stem cell trogocytosis in the bone marrow niche. The research defines mechanisms by which hematopoietic stem cells acquire macrophage-associated markers through trogocytosis—rapid transfer of membrane-bound proteins from adjacent cells—and examines how this...
- The National Heart, Lung, and Blood Institute awarded the University of Wisconsin - Madison $1.211 million on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate neutral sphingomyelinase (NSMASE) in cardiac mechanosensing and mechanical regulation of the heart. The project addresses NSMASE as a critical membrane enzyme involved in sphingolipid metabolism that regulates both normal physiological heart function in response to acute changes in cardiac...
- The National Heart, Lung, and Blood Institute awarded Pediastent LLC $1.472 million on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a first-in-baby clinical study of the CARDIAZN bioresorbable stent, a zinc-alloy device designed to treat pulmonary artery stenosis and coarctation of the aorta in small children. The CARDIAZN stent maintains peak radial strength for approximately six months post-implantation to provide structural support to diseased...
The National Heart, Lung, and Blood Institute awarded The Medical College of Wisconsin, Inc. $668,030 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop radiopaque bioabsorbable metal composite wires for intravascular devices, specifically wire-based braided stents for treatment of arterial defects such as aneurysms. The research addresses a critical gap in endovascular device technology: existing bioabsorbable stents lack both radiopacity for X-ray guided placement and uniform degradation profiles. The project builds on prior work with iron-manganese-nitrogen alloy flow diverters, which demonstrated efficacy in vitro and in vivo but suffered from rapid, non-uniform degradation leading to fractures and reduced long-term healing rates. The team will engineer improved bioabsorbable, radiopaque composite materials to achieve mechanical strength, visibility under imaging, and bioabsorbability while maintaining stent metrics comparable to industry standards. Wire-based braided designs offer advantages over balloon-expandable devices, including low delivery profile, softness, trackability, and high mesh density for closure of arterial defects; successful development could reduce imaging artifacts, chronic thrombosis, inflammation, and complications during reintervention. Work is performed in Wauwatosa, Wisconsin, with a period of performance from August 10, 2026, through May 31, 2030. This is a project grant, the standard NIH research award mechanism for investigator-initiated R01 applications in the cardiovascular research domain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.0k | 8/7/26 |