The National Heart, Lung, and Blood Institute (NHLBI) awarded a $655,636 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Texas Heart Institute (THI), a non-profit organization. The grant supports research to investigate the mechanisms underlying the development of heart failure in patients with single ventricle congenital heart disease (CVD). The key objectives are to gain insights into the intrinsic molecular mechanisms that promote senescence in CVD-related cardiac fibroblasts, explore the metabolic remodeling in these fibroblasts, and determine the deleterious effects of signaling from CVD fibroblasts to cardiomyocytes. This research aims to uncover new therapeutic targets and improve outcomes for CVD patients suffering from heart failure. The grant project period runs from January 1, 2025 to November 30, 2028.
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