Project Grant R01HL180444
- This Project Grant award of $636,822 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Western University of Health Sciences to study the cooperative modulation of piezo ion channels. The research aims to use multi-scale molecular dynamics simulations, high-speed single molecule imaging, and high-resolution electrophysiology to investigate how mechanical forces and channel collisions influence the activity of piezo channels...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, will support research to define cellular pathways that regulate lipid flux and elucidate their impact on cardiovascular disease. The $773,259 award, with a project period from December 2024 to November 2028, will enable the University of California, Los Angeles (UCLA) to: 1) Identify novel cholesterol-responsive proteins in the...
- The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $159,980 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) for the period of March 1, 2025 to August 31, 2026. The grant will fund research to investigate the role of the protein Klotho in the pathogenesis of medial arterial calcification, which is a major risk factor for limb amputation in patients with peripheral artery disease...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Rutgers, The State University of New Jersey, provides $641,816.00 to fund research on the role of connexin hemichannels in the endothelium of resistance arteries and their impact on blood pressure regulation. The research aims to explore an unexplored component of endothelial function, specifically how endothelial calcium entry via connexin hemichannels interacts with...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research on how tissue elasticity and viscosity modulate the signaling between macrophages and fibroblasts in cardiac fibrosis. The $231,552 award, granted to the University of California, San Diego, will fund research to investigate the effects of mechanical stimuli on macrophage-fibroblast interactions and explore the role of a changing mechanical...
- The National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $694,723 project grant to the Board of Regents of the Nevada System of Higher Education, operating through the University of Nevada, Reno (UNR). The grant supports research to characterize the mechanisms by which thin-stranded pericytes, a specific type of perivascular mural cell, regulate blood flow and oxygen delivery within capillary networks. Specifically,...
- This Project Grant award of $249,000.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure. The key objectives are to test the hypothesis that impaired intracellular calcium signaling and somatodendritic release of vasopressin lead to the hyperexcitability and excess peripheral vasopressin...
- The University of South Florida was awarded a $2,074,842 Project Grant by the National Heart, Lung, and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to investigate how post-translational modifications of the CaMKII protein during chronic diabetes impact endothelial small-conductance calcium-activated potassium (SK) channel activity, coronary microvascular function, and myocardial blood flow. The overall goal is to expand scientific understanding of the mechanisms underlying...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $733,371 in funding to the University of California, Davis to conduct research on the pressure regulation of vascular Cav1.2 channels. The research aims to advance understanding of the role of vascular smooth muscle Cav1.2 channels in the myogenic response and vascular reactivity, and how these dynamics may be altered in disease states. The award period runs from August 2025 to May 2029. The research will utilize sophisticated experimental approaches to test hypotheses related to how pressure directly modulates Cav1.2 channel spatiotemporal properties, the underlying mechanisms involving kinase activity and specific phosphorylation sites, and the implications for vascular function in health and disease. This work has high translational impact, as it may uncover new therapeutic avenues for manipulating Cav1.2 channels in cardiovascular disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $733.4k | 8/4/25 |