Project Grant R01HL179809
- This federal Project Grant award of $701,791 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of neddylation, a post-translational modification, in protecting endothelial cell integrity and function. The research aims to establish the pathophysiological significance of neddylation in the endothelium and identify key downstream effectors. The University of Nebraska, Lincoln is the awardee and will utilize...
- This federal Project Grant award of $249,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of Sphingosine Kinase 1 (SPHK1) in the vascular smooth muscle cell hyperproliferation observed in Supravalvular Aortic Stenosis (SVAS) and Patent Ductus Arteriosus (PDA). The research aims to elucidate the mechanistic links between defective elastic lamellae and excessive smooth muscle cell accumulation in these...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $768,198 to the Augusta University Research Institute, Inc. (dba Georgia Health Sciences) to conduct research on the function and transcriptional regulation of the Leiomodin1 (LMOD1) gene, which is associated with coronary artery disease (CAD). The research aims to elucidate the role of LMOD1 in maintaining normal vascular smooth muscle cell function...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $766,920 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant, effective May 15, 2025 through February 28, 2029, will support research by Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking skeletal muscle health and vascular function in obesity. The research aims to...
- This federal Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) provides $633,720 to The Washington University to develop and apply chemical biology approaches for understanding protein arginylation. The key objectives are to: 1) establish a chemical proteomics platform to comprehensively identify arginylation sites in cardiovascular tissues, 2) elucidate the epigenetic and functional impacts of protein...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports the development of a lesion-targeted nanotherapeutic to address vascular smooth muscle cell (VSMC) dysfunction and mitigate neointimal hyperplasia (NIH), which is a significant issue arising from vascular damage during interventions. The project aims to integrate in vitro transcribed CARMN RNA (a long non-coding RNA critical...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of heterochromatin dynamics in the plasticity of vascular smooth muscle cells (SMCs). The $756,224 grant, awarded to Yale University on August 15, 2025, will fund investigations into how epigenetic regulation of heterochromatin, particularly through the histone methyltransferase SUV39H1, influences SMC phenotypic transitions. The...
- This $247,729 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of the MEIS1 transcription factor in regulating vascular smooth muscle cell (VSMC) phenotypic switching associated with vascular diseases such as atherosclerosis and restenosis. The project aims to elucidate how MEIS1 controls the expression of the MYOCD gene, a key regulator of the VSMC contractile state, and the impact of...
- This Project Grant award, valued at $748,965.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northwestern University for a research project titled "Vascular Proliferative Resilience - Summary in Adults". The project aims to investigate the dynamics, spatial context, and molecular regulators of endothelial cell proliferation in the aorta, with the goal of deciphering the mechanisms underlying the maintenance of vascular...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include developing inducible vascular smooth muscle cell-specific knockout mice to study the effects of neddylation disruption on vascular remodeling, aneurysm formation, and coronary artery disease progression. The award period runs from September 15, 2025 to June 30, 2029 and supports this comprehensive research effort to advance understanding of the molecular mechanisms underlying vascular smooth muscle cell phenotypic switching and its implications for cardiovascular health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $766.7k | 9/12/25 |