Project Grant R01HL177084
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Rutgers, The State University of New Jersey, provides $641,816.00 to fund research on the role of connexin hemichannels in the endothelium of resistance arteries and their impact on blood pressure regulation. The research aims to explore an unexplored component of endothelial function, specifically how endothelial calcium entry via connexin hemichannels interacts with...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $733,371 in funding to the University of California, Davis to conduct research on the pressure regulation of vascular Cav1.2 channels. The research aims to advance understanding of the role of vascular smooth muscle Cav1.2 channels in the myogenic response and vascular reactivity, and how these dynamics may be altered in disease states. The award period runs from...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $775,720 project grant to Yale University under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to conduct research on the role of endothelial protocadherins in vascular development and disease. The project aims to: 1) determine the effects of knocking out or inhibiting the protocadherin gamma (PCDHG) cluster in endothelial cells in mouse models of vascular inflammation, 2) elucidate the mechanism by which...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $239,800 to Louisiana State University Health Sciences Center-Shreveport to investigate the role of arterial baroreceptors in the development of hypertension. The research aims to develop novel methods to selectively target these sensory neurons and understand how chronic elevations in blood pressure disrupt their function, potentially contributing to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,092,000 to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system and their impact on blood pressure, vascular function, and arterial stiffness. The research aims to advance understanding of the regulatory circuits governing vascular function and arterial structure,...
- This federal Project Grant award of $701,791 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of neddylation, a post-translational modification, in protecting endothelial cell integrity and function. The research aims to establish the pathophysiological significance of neddylation in the endothelium and identify key downstream effectors. The University of Nebraska, Lincoln is the awardee and will utilize...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
- The National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $432,431 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the San Jose State University Research Foundation. The grant, awarded on January 15, 2025, aims to study the deformability and subpopulation characteristics of red blood cells in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared to healthy controls. The research will...
- The National Heart, Lung, and Blood Institute (NHLBI), via the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $564,445 Project Grant to the University of Texas Health Science Center at Houston (UTHealth) to fund research on "Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease." The 6-year grant, starting on March 1, 2025 and ending on December 31, 2031, supports three complementary research projects focused on investigating the upstream regulation...
- This Project Grant award of $636,822 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Western University of Health Sciences to study the cooperative modulation of piezo ion channels. The research aims to use multi-scale molecular dynamics simulations, high-speed single molecule imaging, and high-resolution electrophysiology to investigate how mechanical forces and channel collisions influence the activity of piezo channels...
The National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $694,723 project grant to the Board of Regents of the Nevada System of Higher Education, operating through the University of Nevada, Reno (UNR). The grant supports research to characterize the mechanisms by which thin-stranded pericytes, a specific type of perivascular mural cell, regulate blood flow and oxygen delivery within capillary networks. Specifically, the project will investigate the ion channels, signaling pathways, and contractile machinery that enable thin-stranded pericytes to constrict capillaries in response to changes in intraluminal pressure. The research also aims to determine if pericyte-mediated capillary regulation is essential for tuning the transit time of red blood cells to facilitate local oxygen release. This 4-year project grant runs from September 1, 2025 to June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.7k | 9/1/25 |