Project Grant R01HL180055
- This federal Project Grant award of $772,808 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of cardiac metabolism and glutamine production in heart failure and cardiac fibrosis. The project, led by Temple University, aims to investigate whether cardiomyocyte glutamine production plays a pivotal role in fibroblast activation and cardiac fibrosis. Key research activities include generating a cardiomyocyte-specific...
- The Project Grant award of $2,868,266.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Temple University to investigate the role of the vascular enzyme pyruvate kinase M2 (PKM2) in mediating hypertension and vascular remodeling. The project aims to explore how angiotensin II-induced activation of PKM2 in vascular smooth muscle cells contributes to hypertension and remodeling of both conductance and...
- This Project Grant award of $673,642.00 was provided by the National Heart Lung and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to study the role of lysosomes in arrhythmia and sudden cardiac death. The principal investigator will investigate whether cardiac lysosomes, similar to mitochondria, can contribute to arrhythmic risk during cardiomyopathy by releasing calcium and triggering calcium sparks in the sarcoplasmic reticulum. The project aims to elucidate the specific...
- This $385,381 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of dynamic biological hydrogels to modulate cardiac remodeling following myocardial infarction. The primary goals are to: 1) Improve the mechanical stability and stiffness of cardiac extracellular matrix hydrogels compared to existing therapies, and 2) Leverage changes in extracellular matrix composition to promote a more regenerative...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $235,608 to the University of Texas Southwestern Medical Center to conduct research on the impact of defective lipoylation on cardiac function and failure. The research aims to characterize the underlying mechanisms of cardiometabolic disorders using an inborn error of metabolism condition caused by LIPT1 gene deficiency as a model system. Key objectives include...
- This federal Project Grant award of $165,366 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the role of transcription factors KLF2 and KLF4 in cardiac fibroblast function and their relationship to heart failure. The award was granted to Drexel University, a private research university in Pennsylvania, to conduct this research from September 1, 2025 through August 31, 2030. The project aims to advance the...
- This federal Project Grant award of $605,253 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by the University of Delaware to investigate the protective role of cardiac HSP90β ablation/inhibition for mitigating myocardial infarction and ischemia-reperfusion injury. The research aims to thoroughly examine if cardiac-specific HSP90β knockout confers cardioprotection, potentially by preserving mitochondrial membrane integrity....
- This federal Project Grant award of $169,020.00 was provided by the National Heart Lung and Blood Institute (NHLBI), which operates under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pennsylvania investigating the impact of obesity and diabetes on coronary microvascular defects in heart failure with preserved ejection fraction (HFpEF). The research will use an animal model of HFpEF to compare the temporal progression...
- This $651,967 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to elucidate the role of cardiac tissue-resident macrophages in heart failure progression. The principal investigator at the Texas Heart Institute will conduct research over a 5-year period from August 2025 to May 2030 to determine how macrophage senescence contributes to cardiomyocyte dysfunction, inflammation, and impaired clearance of cellular debris in...
- This Project Grant award of $720,526 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of the TBC1D2B protein in the formation of new blood vessels and vascularization after ischemic injury. The funded research aims to uncover the underlying regulatory mechanisms by which the TBC1D2B protein, which interacts with phosphatidylinositol lipids, impacts the formation of endothelial cell tubes crucial for...
The federal Project Grant award titled "Lysosomal Ionic Dysregulation in Heart Disease" was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University-Of The Commonwealth System Of Higher Education in Philadelphia, PA. The $717,558 award, which runs from September 4, 2025 to June 30, 2030, will support research to investigate the role of the lysosomal two-pore channel (TPC2) in promoting cardiomyocyte death and impaired cardiac function during heart failure progression following acute myocardial infarction. The research aims to determine if sustained increases in TPC2 activity drive pathological cardiac remodeling, and whether TPC2-selective inhibition can prevent heart failure development. This project grant aligns with the Cardiovascular Diseases Research program's objectives to foster basic, translational, clinical, and population science research to advance understanding of cardiovascular conditions and develop new treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $717.6k | 9/4/25 |