The National Heart, Lung, and Blood Institute (NHLBI) awarded a $732,119 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Temple University-Of The Commonwealth System Of Higher Education, a public research university located in Philadelphia, Pennsylvania. The grant, which runs from December 15, 2024 to November 30, 2028, supports research to investigate the role of the enzyme pyruvate kinase M2 (PKM2) in vascular remodeling and hypertension. The project aims to explore how PKM2 activation in vascular smooth muscle cells mediates hypertension and vascular remodeling, including mechanisms involving both metabolic and non-metabolic effects. The research will utilize genetically or pharmacologically altered mouse models infused with angiotensin II to study the cell types and signaling pathways involved. Accomplishing the proposed aims is expected to advance the understanding of the mechanisms leading to the development of hypertensive vascular remodeling and provide insights for future translational research and new therapies.
Generated 1/28/25, 8:31 AM