The project grant award R01HL171396, totaling $385,381.00, was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the development and evaluation of injectable, highly elastic silk-based hydrogels containing fetal heart-derived cardiac extracellular matrix (ECM) for cardiac repair following myocardial infarction. The objective is to create a biomaterial that can mechanically stabilize the infarcted ventricular wall while promoting more favorable remodeling and improved diastolic function. The research will be conducted by Tufts University and is expected to be completed by November 30, 2028. The grant will fund in vitro characterization of the hydrogel formulations and in vivo assessment of their impact on cardiac remodeling and function in a rat model of myocardial infarction.
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