Project Grant R01HL179819
- Federal Grant Award Summary Boston Children's Hospital received a $686,610 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2026, with a completion date of March 31, 2030. The award funds research to elucidate the molecular mechanisms by which the transcription factor MECOM (MDS1/EVI1 Complex Locus) drives endothelial inflammation and atherosclerosis progression. The research builds on...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant of $139,822 (awarded May 4, 2026; completion April 30, 2028) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct fundamental research on the mechanisms of endothelial cell differentiation during vasculogenesis. The research focuses on understanding how mesodermal precursor cells develop into endothelial cells and subsequently differentiate...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $144,817 Project Grant on May 8, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support basic science research investigating the molecular mechanisms underlying congenital heart disease, specifically left ventricular noncompaction. The award funds a two-year research initiative (through April 30, 2028) examining how sphingosine-1-phosphate...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $1.73 million Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective July 1, 2026, through June 30, 2028, to conduct fundamental research on emperipolesis as a driver of platelet heterogeneity and function. The project delivers scientific research services investigating how neutrophil-megakaryocyte interactions (emperipolesis) generate functionally...
- Federal Grant Award Summary Boston Children's Hospital received a $169,160 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded December 1, 2026, with completion targeted for May 31, 2029. The award funds research to dissect the spatial and molecular dynamics of immune-vascular crosstalk in induced pluripotent stem cell (iPSC)-based therapies for vascular diseases. The project delivers three primary...
- Federal Project Grant Award Summary Boston Children's Hospital received an $833,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with a completion date of May 31, 2029. The grant funds basic research investigating the pro-regenerative potential of PONTIN (an AAA+ ATPase protein) in cardiac tissue, with the objective of identifying druggable pathways to stimulate heart...
- Federal Project Grant Award Summary Award Details: Brigham and Women's Hospital Inc. received a $1.54 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for June 30, 2029. The award funds development of a novel small interfering RNA (siRNA) therapy delivered via lipid nanoparticles (LNPs) designed to simultaneously reduce cholesterol synthesis in...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $5.96 million Project Grant on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multi-omic investigation optimizing hematopoietic stem cell transplantation (HCT) outcomes. The five-year research initiative, scheduled for completion by May 31, 2030, will deliver mechanistic and translational science research aimed at improving...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $866,279 Project Grant on May 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate coordinated protein synthesis and degradation mechanisms during neonatal heart regeneration. The research project, scheduled for completion by January 31, 2031, examines how neonatal cardiomyocytes rapidly adapt to ischemic injury through proteome...
Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $1,628,604 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective July 15, 2026, with a completion date of June 30, 2028. The research is being conducted in Boston, Massachusetts. Research Scope: This project investigates the molecular regulation of atherosclerosis, specifically focusing on the role of endothelial cell clearance and CD47 (cluster of differentiation 47) signaling in mitigating vascular inflammation and endothelial dysfunction. The research addresses the critical scientific gap that 70–80% of patients receiving lipid-lowering therapies continue to experience major adverse cardiovascular events. The funded work will generate foundational mechanistic research and scientific knowledge to identify novel molecular drivers of atherosclerosis and develop targeted therapeutic strategies that preserve endothelial integrity and resolve chronic vascular inflammation—key pathological drivers of plaque destabilization, myocardial infarction, and stroke. As a leading NIH-funded research institution, Boston Children's Hospital will deliver basic and translational science outputs, including experimental data, publications, and therapeutic insights intended to inform next-generation anti-atherosclerotic drug development and clinical treatment approaches.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/14/26 |