Project Grant K99HL186058
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $865,286 to Boston Children's Hospital (The Children's Hospital Corporation) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of June 30, 2029. This research initiative will produce a high-resolution spatiotemporal lineage map of cardiac development by integrating advanced lineage tracing, spatial, and single-cell...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- Federal Project Grant Award Summary Boston Children's Hospital received an $833,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with a completion date of May 31, 2029. The grant funds basic research investigating the pro-regenerative potential of PONTIN (an AAA+ ATPase protein) in cardiac tissue, with the objective of identifying druggable pathways to stimulate heart...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant totaling $865,694 (awarded June 5, 2025; completion date April 30, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on neuropilin-2 (NRP2) signaling and lymphatic function. The research focuses on understanding how NRP2, a transmembrane receptor in lymphatic endothelial cells, functions as a dynamic regulator of...
- Summary This National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Diseases Research project grant (CFDA 93.837) awarded $866,279 to Boston Children's Hospital, with performance in Boston, MA, supports research investigating coordinated protein synthesis and degradation mechanisms during neonatal heart regeneration. The research will generate scientific insights into how neonatal cardiomyocytes maintain protein homeostasis and rapidly adapt to ischemic injury—a regenerative capacity...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant of $117,525 on July 7, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate cellular adaptation mechanisms in response to one-carbon metabolism perturbation. The research focuses on understanding how erythroid cells respond to folate deficiency through a combination of genome-wide CRISPR screening, RNA sequencing, and molecular...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $511,987 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 27, 2025, with a completion date of May 31, 2029. This award funds a comparative research study investigating the molecular mechanisms of lamin A/C (LMNA)-related dilated cardiomyopathy, a severe form of adult-onset heart disease. The...
- Federal Grant Award Summary Boston Children's Hospital received a $279,644 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for August 31, 2027. The grant funds research to develop and validate time to return of spontaneous circulation (ROSC) as a novel primary outcome measure for pediatric in-hospital cardiac arrest (P-IHCA) clinical trials. The research...
- Federal Grant Award Summary Boston Children's Hospital received a $5.96 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion expected May 31, 2030. The grant funds "Optimizing HCT Outcomes: A Multi-Omic Investigation," a research initiative focused on improving outcomes for patients undergoing hematopoietic stem cell transplantation (HCT), a critical...
- Federal Project Grant Award Summary Boston Children's Hospital received a $809,162 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with a completion date of June 30, 2030. This award supports research investigating pulmonary ionocyte function and development using induced pluripotent stem cell (iPSC)-derived airway epithelium models. The research aims to advance...
Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant totaling $144,817 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period May 8, 2026 through April 30, 2028. This research initiative, titled "Endocardial S1PR1 Internalization Drives Congenital Heart Disease via Notch Signaling Dysregulation," will produce fundamental scientific knowledge regarding the molecular mechanisms underlying left ventricular noncompaction (LVNC), a form of congenital heart disease affecting approximately 1% of live births. The research outputs will include advanced characterization of how sphingosine-1-phosphate receptor 1 (S1PR1) regulates Notch1 signaling during cardiac development and identification of potential therapeutic targets through pharmacologic intervention. The research will deliver specific investigative products across two research aims: (1) determination of the impact of endocardial-specific S1PR1 gain-of-function on trabecular remodeling and Notch signaling activity through advanced mouse genetics; and (2) evaluation of targeted pharmacologic S1PR1 inhibition as a potential therapeutic approach to rescue defective endocardial signaling and restore normal cardiac morphology. Deliverables will include biochemical and transcriptomic data, in vivo cardiac phenotyping results, and scientific publications advancing understanding of G protein-coupled receptor signaling in congenital heart disease pathogenesis. The project is conducted at Boston Children's Hospital under the mentorship of established investigators in sphingosine-1-phosphate biology and developmental cardiology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $144.8k | 5/12/26 |