Project Grant R01HL177662
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $775,720 project grant to Yale University under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to conduct research on the role of endothelial protocadherins in vascular development and disease. The project aims to: 1) determine the effects of knocking out or inhibiting the protocadherin gamma (PCDHG) cluster in endothelial cells in mouse models of vascular inflammation, 2) elucidate the mechanism by which...
- This $247,729 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the role of the MEIS1 transcription factor in regulating vascular smooth muscle cell (VSMC) phenotypic switching associated with vascular diseases such as atherosclerosis and restenosis. The project aims to elucidate how MEIS1 controls the expression of the MYOCD gene, a key regulator of the VSMC contractile state, and the impact of...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $560,828 to Yale University to conduct research on the role of linker histones in regulating the lymphoid differentiation potential of hematopoietic stem and progenitor cells. The research aims to define the molecular pathway by which specific linker histone isoforms or abundance influence the lineage output of multipotent...
- This federal Project Grant award of $248,955 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by Howard University to characterize the roles of bivalent chromatin domains in regulating CD4+ T cell differentiation and plasticity. The award will enable the principal investigator to expand their biological skills and apply a novel single-cell epigenetic profiling technique (iSCCHIC-seq) to study how bivalent domains regulate...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to define the role of the RNA-binding protein G3BP1 in blood vessel formation. The $147,486 award to Yale University will fund the development of a novel zebrafish model to investigate how G3BP1-mediated post-transcriptional regulation impacts vascular development. The overall objective is to enhance understanding of the gene regulatory networks...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $331,344.00 to The Leland Stanford Junior University to investigate the gene regulatory mechanisms of the coronary artery disease gene PRDM16 and its impact on smooth muscle cell phenotypic modulation. The research aims to determine how PRDM16, an epigenetic modifier, regulates the transition of smooth muscle cells into protective "fibromyocytes"...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- This federal Project Grant award of $249,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of Sphingosine Kinase 1 (SPHK1) in the vascular smooth muscle cell hyperproliferation observed in Supravalvular Aortic Stenosis (SVAS) and Patent Ductus Arteriosus (PDA). The research aims to elucidate the mechanistic links between defective elastic lamellae and excessive smooth muscle cell accumulation in these...
- The federal Project Grant award of $535,556.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Alabama at Birmingham (UAB). The funding will support a research project to investigate the role of a novel histone modification, H3T32 O-GlcNAc, in endothelial cell dysfunction and atherosclerosis. The 5-year project aims to elucidate the epigenetic features of this histone modification under...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $787,267 to Yale University from January 1, 2025 to November 30, 2028 to conduct research aimed at determining whether genetic deletion of the DHCR24 enzyme in macrophages or hepatocytes can attenuate the progression of atherosclerosis. The project will exploit novel animal models and cutting-edge genomic and metabolomic technologies to evaluate the therapeutic...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of heterochromatin dynamics in the plasticity of vascular smooth muscle cells (SMCs). The $756,224 grant, awarded to Yale University on August 15, 2025, will fund investigations into how epigenetic regulation of heterochromatin, particularly through the histone methyltransferase SUV39H1, influences SMC phenotypic transitions. The research aims to enhance understanding of how SMCs can alter their identity, which is relevant to the development and treatment of cardiovascular diseases. Key focus areas include the impact of SUV39H1 and H3K9me3 heterochromatin on SMC differentiation, proliferation, and migration, as well as the regulation of genes like KLF4 and KDM4A. The project is expected to run through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $756.2k | 8/8/25 |