Project Grant R01HL173111
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $2,442,173 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Leland Stanford Junior University (Stanford University) to identify genes and pathways that influence the risk of vascular diseases such as coronary artery disease (CAD) and pulmonary arterial hypertension (PAH). The 5-year award, effective August 15, 2025, will leverage innovative CRISPR genomics approaches to characterize gene...
- This federal Project Grant award of $249,000.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of Sphingosine Kinase 1 (SPHK1) in the vascular smooth muscle cell hyperproliferation observed in Supravalvular Aortic Stenosis (SVAS) and Patent Ductus Arteriosus (PDA). The research aims to elucidate the mechanistic links between defective elastic lamellae and excessive smooth muscle cell accumulation in these...
- This federal Project Grant award of $687,517 from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research to elucidate the role of the gene Leiomodin1 (LMOD1) in the formation of mature blood vessels, which is critical for restoring blood flow in peripheral artery disease (PAD). The research, to be conducted by the University of Alabama at Birmingham from May 2025 to February 2030, aims to determine how LMOD1 regulates the vascular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $331,344.00 to The Leland Stanford Junior University to investigate the gene regulatory mechanisms of the coronary artery disease gene PRDM16 and its impact on smooth muscle cell phenotypic modulation. The research aims to determine how PRDM16, an epigenetic modifier, regulates the transition of smooth muscle cells into protective "fibromyocytes"...
- This Project Grant award of $511,987.00 from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a comparative study on gene regulatory and structural mechanisms in lamin-related cardiomyopathy. The project aims to directly compare two prevailing hypotheses on the pathogenesis of lamin A/C-related dilated cardiomyopathy (LMNA-DCM) - the gene regulatory hypothesis and the structural hypothesis - to advance the mechanistic...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $766,920 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant, effective May 15, 2025 through February 28, 2029, will support research by Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking skeletal muscle health and vascular function in obesity. The research aims to...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
- This federal Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) provides $633,720 to The Washington University to develop and apply chemical biology approaches for understanding protein arginylation. The key objectives are to: 1) establish a chemical proteomics platform to comprehensively identify arginylation sites in cardiovascular tissues, 2) elucidate the epigenetic and functional impacts of protein...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $768,198 to the Augusta University Research Institute, Inc. (dba Georgia Health Sciences) to conduct research on the function and transcriptional regulation of the Leiomodin1 (LMOD1) gene, which is associated with coronary artery disease (CAD). The research aims to elucidate the role of LMOD1 in maintaining normal vascular smooth muscle cell function and its potential as a therapeutic target for CAD. Key objectives include characterizing the CAD phenotype in LMOD1 mutant mice, investigating the nuclear interaction between LMOD1 and the transcription factor MYBBP1A, and determining the transcriptional regulation of LMOD1 expression in vivo. The award period runs from January 1, 2025 to November 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $768.2k | 12/13/24 |