This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...
This $750,162 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will fund research by The Children's Hospital of Philadelphia (CHOP) to investigate the role of lymphatic dysfunction in the development of post-lung transplant complications. The key objectives of this 4-year project include: 1) determining the mechanisms of lymphatic vascular function after lung transplantation, 2) evaluating...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $167,940 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) with a project period from Sep 20, 2024 to Aug 31, 2029. The grant aims to develop a novel mouse model of flow-induced pulmonary hypertension (PH) that better represents the physiological conditions observed in patients with congenital heart disease. Additionally, the project...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $696,870 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) from August 1, 2024 to May 31, 2028. The primary focus of this award is to conduct research on the functional characterization of the endothelial cell niche for hematopoietic stem...
This $502,294 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837) aims to integrate advanced biomaterials and targeted delivery of lipid nanoparticles into current lymphedema surgical procedures to enhance lymphangiogenesis and improve treatment outcomes. The key objectives are to: 1) Evaluate lymphangiogenic hydrogels and their capacity to induce lymphangiogenesis and facilitate engraftment...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $116,278 to the University of South Florida to investigate the role of the plasminogen activator (PA) pathway in lymphatic malformations. The key research activities include: Assessing the expression of key PA enzymes and utilizing in vitro zymography to evaluate matrix metalloproteinase (MMP) activation related to lymphatic valve defects...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $508,436 to The University of Texas Southwestern Medical Center to investigate the genetic and environmental factors contributing to the development of complex lymphatic anomalies (CLAs), a group of rare vascular diseases. The research team will use a novel mouse model to test the hypothesis that CLA formation requires both a genetic mutation in lymphatic...
Larix Bioscience LLC received a $245,728 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the company's research and development of novel therapies for improving lymphatic dysfunction, a complication commonly associated with obesity and diabetes. Specifically, the grant funds the generation and preclinical evaluation of albumin and Fc fusion protein therapeutics targeting adrenomedullin...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,218,392.00 to Yale University to conduct research on the role of the lymphatic system in the pathogenesis of cerebral small vessel disease (CSVD) associated with chronic hypertension. The research aims to characterize the coupling between the glymphatic and lymphatic systems, determine how lymphatic drainage deficits contribute to...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded a $2,087,677 Project Grant (R01HL176018) to Children's Hospital Los Angeles to investigate the role of the chromatin remodeling factor CHD7 in regulating cardiac and craniofacial lymphatic vessel development. The project aims to perform lineage tracing, single-cell multi-omic analysis, and spatial transcriptomics to elucidate how CHD7 regulates gene...