The National Heart, Lung, and Blood Institute (NHLBI) awarded a $108,405 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Washington University in St. Louis to study the role of primary cilia in regulating vascular stability during embryonic development. The objectives are to determine if endothelial cell cilia respond to changes in blood flow, define the mechanism by which cilia influence vascular mural cell recruitment and differentiation, and model the impact of human genetic variants associated with congenital heart defects using the zebrafish model. This innovative research aims to provide novel insights into the mechanosensitive functions of primary cilia and clarify their influence on vascular stabilization processes and congenital cardiovascular disorders. The project will be conducted from July 1, 2024 through June 30, 2026 by the university's Office of Sponsored Research Services Division.
Generated 1/28/25, 8:19 AM