The National Heart, Lung, and Blood Institute (NHLBI) awarded a $197,640 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Johns Hopkins University. The grant supports research by Dr. Lee Goeddel, a cardiac anesthesiologist and intensivist, to investigate the relationship between low cardiac output, renal perfusion, and the development of acute kidney injury in cardiac surgery patients. Over 5 years, the project will use data science, urine biomarkers, and...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $498,991.40 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas. The grant, effective January 2, 2025 through December 31, 2027, will support the development of microphysiological systems to investigate molecular pathways and cardiomyocyte function in response to hypoxic cardiac injury associated with myocardial infarction and ischemia-reperfusion injury. The project aims to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research supports research to investigate the role of the serine-threonine kinase, serum glucocorticoid kinase 1 (SGK1), in cardiometabolic heart failure with preserved ejection fraction (CMET HFPEF). The $732,779 award to the University of Utah aims to: (1) determine the role of cardiac-specific SGK1 in regulating heart function, metabolism, and inter-organ...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $654,530 to the University of Utah to investigate the role of the serine-threonine kinase SGK1 in regulating cardiac function and metabolism in cardiometabolic heart failure with preserved ejection fraction (cMet HFPEF). The 4-year project aims to determine how cardiac-specific SGK1 signaling, particularly through its phosphorylation of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program provides $564,445 in funding to the University of Texas Health Science Center at Houston (UTHealth) to conduct research focused on targeting hypoxia-inducible factors (HIFs) for heart and lung disease. The research program consists of three complementary projects: 1) Exploring the upstream regulation of HIFs by prolyl hydroxylase domain enzymes...
This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research, provides $815,229 to The University of Texas Southwestern Medical Center to conduct advanced research on cardiovascular disease susceptibility and resilience in Black Americans. The key objectives are to: 1) Identify proteins and protein networks associated with clinical and subclinical cardiac dysfunction, 2) Pinpoint proteins and networks linked to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, provides $249,000.00 in funding to Texas A&M University System Health Science Center to conduct research on the regulation of vasopressin neurons in a rodent model of heart failure. The key goals of the research are to investigate how vasopressin neurons self-regulate their excitability and paracrine release of vasopressin, and...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $528,179 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Miami. The grant supports research to investigate whether extracellular vesicles mediate the systemic effects of ischemia training on monocyte reprogramming, and to determine if regulation of the DHCR24 enzyme in myeloid cells impacts limb perfusion, function, and arteriogenesis in peripheral arterial disease. The research...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, provides $402,117 to the University of North Carolina at Chapel Hill. The award will support the adaptation and pilot testing of a family-centered intervention, SUCCEED-ICU, designed to improve long-term outcomes for survivors of acute respiratory failure. The project aims to: 1) adapt the existing SUCCEED intervention for use in acute respiratory...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $156,600 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The University of Texas Southwestern Medical Center (UT Southwestern). The 5-year grant will support research to define the role of the PHF7 protein in driving cardiac reprogramming and improving heart function following a myocardial infarction. Specifically, the project aims to: 1) Characterize...