Project Grant R01HL177837

Award Date 6/1/25
Completion Date 3/31/29
Dollars Obligated $740K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
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This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will provide $740,196 to Case Western Reserve University from June 1, 2025 to March 31, 2029.

The primary objective of this research project is to investigate the potential adverse effects of continuous positive airway pressure (CPAP) on lung development in preterm infants. Using in vivo mouse models and human fetal airway smooth muscle cell cultures, the researchers will examine how CPAP-induced mechanical stretch impacts airway hyperreactivity through multiple mechanosensitive pathways involving the Piezo family of mechanosensors, extracellular matrix components, and plasma membrane caveolae. The goal is to elucidate the underlying mechanisms by which CPAP, a commonly used non-invasive respiratory therapy, may contribute to long-term respiratory issues in former preterm infants, in order to guide clinical care and minimize these unintended consequences.

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