This $248,955 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research by Howard University to characterize the roles of bivalent chromatin domains in regulating CD4+ T cell differentiation and plasticity. Key objectives include: 1) identifying plasticity-related bivalent domains that dynamically change during T cell differentiation, 2) examining chromatin structure changes at these domains, and 3) using an EZH2 inhibitor to validate the regulatory roles of bivalent domains on target genes. This work aims to advance understanding of epigenetic mechanisms controlling T cell differentiation, with potential implications for developing new therapeutic targets for immune-related diseases. The grant period runs from March 1, 2025 to February 29, 2028.
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