Project Grant R01HL175510
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Louisville for $108,030.00 supports research on the role of emergency granulopoiesis in wound healing after myocardial infarction. The key objectives are to determine if myocardial infarction-induced emergency granulopoiesis gives rise to neutrophils with differential function, and if emergency granulopoiesis contributes to post-myocardial infarction...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $771,750 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Los Angeles (UCLA) to investigate the role of macrophages in regulating cardiac muscle metabolism after myocardial infarction. The project aims to shed novel insights into how macrophages recruited to the infarcted heart disrupt cardiac muscle metabolism and lead to decreased NAD pools, which play a critical...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $425,505 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Louisiana State University Health Sciences Center-Shreveport (LSU Health Sciences Center-Shreveport) to investigate the role of cell-specific Programmed Death-Ligand 1 (PD-L1) in cardiac pathophysiology following ischemic injury and cancer. The project aims to elucidate the specific mechanisms by which fibroblast-specific and myeloid...
- The University of Pittsburgh was awarded a $791,485 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) on August 1, 2025. The grant will support research on "Treatment of Post-Infarction Cardiac Remodeling Using Image-Guided Delivery of MicroRNA-Loaded Microbubbles and Ultrasound-Mediated Cavitation". The research aims to develop an innovative ultrasound-based approach for targeted delivery of anti-microRNA-92a therapy to...
- This federal Project Grant award of $740,037, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on the regulation of angiogenesis (blood vessel formation) by cardiac fibroblasts following myocardial infarction. The key objectives are to investigate the temporal and spatial expression of pro- and anti-angiogenic factors secreted by cardiac fibroblasts to support cardiac repair and increase vascular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $637,126 to the Trustees of Indiana University, doing business as Indiana University Indianapolis, to conduct research on the regulatory mechanisms of neovascularization, cardiomyocyte survival, and endothelial cell-cardiomyocyte crosstalk in myocardial infarction. The project aims to elucidate the roles of novel endothelial cell- and cardiomyocyte-specific...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $402,911 Project Grant to The Trustees of Columbia University in the City of New York to develop a pericardial mRNA therapy for the treatment of myocardial infarction (heart attack). The research aims to create a new anti-inflammatory drug based on previous studies of stem cell derivatives for heart repair, which will be administered via minimally invasive...
- The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...
- This federal Project Grant award, valued at $765,288.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research at the University of California, San Diego (UCSD) to investigate the biological mechanisms of the infarct borderzone - the complex and dynamic region between areas of cell death and normal tissue in the heart following a myocardial infarction. The research aims to advance...
- This Project Grant award of $796,189.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to define the dynamics of neutrophil subpopulations and their role in inflammatory lung injury and repair. The study aims to identify the distinct functions of the CXCR2 and CXCR4 chemokine receptors in regulating neutrophil trafficking and activation during acute lung inflammation, with the goal of developing...
The University of Louisville was awarded a $728,529 project grant by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant will fund research to investigate the relationship between the acute immune response and wound healing processes that occur following a myocardial infarction (MI). The project aims to characterize how "emergency granulopoiesis" - the acute increase in neutrophil production in response to MI - impacts neutrophil function and the extent to which it influences ventricular remodeling and scar formation. The research seeks to provide insights into how the heart communicates with the bone marrow to initiate this emergency neutrophil production response. The grant period runs from September 15, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $728.5k | 9/12/25 |