This Project Grant award, with a total funding amount of $265,151.00, was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the University of Southern California. The project aims to use mathematical modeling and experiments to understand what regulates leakiness in the lymphatic system, with the goal of developing strategies to modulate lymphatic permeability. The research will investigate how lipids regulate CD36, a long-chain fatty acid translocase,...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $299,990 Project Grant to Worcester Polytechnic Institute to investigate how tissue stiffness and fluid flow coordinate to regulate lymphatic capillary growth and function. This two-year award, issued on February 1, 2022 with a completion date of January 31, 2024, falls under the NSF Directorate for Engineering's CFDA #47.041 Engineering program. The program seeks to improve quality of life...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $200,000 Project Grant to Lutheran University Association Inc., doing business as Valparaiso University, to develop a liposomal drug delivery platform for the treatment of lymphatic filariasis - a neglected tropical disease. The project aims to optimize the lymphatic uptake of existing lymphatic filariasis drugs and improve their efficacy against adult filarial worms. This will be achieved by synthesizing and...
This $249,987 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research on the structure and function of lipid antigen selection and presentation. The project aims to develop new computational tools to model lipid/protein assemblies and study the mechanisms by which lipids interact with proteins important for immune system function. Key objectives include: (1) creating machine learning-based predictive models of lipid/protein...
This $378,750 federal Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Saint Louis University focused on elucidating the voltage-sensing mechanisms of ion channels within dynamic lipid membranes. The 5-year project aims to investigate the regulatory interplay between the voltage-sensing domain of voltage-gated ion channels and the ordered lipid membrane domains enriched...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $342,318 supports research at the University of Wisconsin - Madison to develop a novel theoretical and computational framework for modeling the mechanical deformation and interactions of biomembranes with transport and electrochemical processes. The 3-year research project, starting on Sep 1, 2024, aims to create an open-source computational tool to model key biomembrane phenomena like endocytosis,...
This $208,784 federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project to study the emergent dynamics and scaling laws of bioinspired lipid membranes. The University of Arizona, as the primary awardee, will integrate experimental methods such as neutron spectroscopy, NMR, and flicker spectroscopy with molecular dynamics simulations. This integrated approach aims to establish the...
This $307,015 federal Project Grant awarded by the National Science Foundation's Biological Sciences program to the University of Utah aims to investigate the mechanisms regulating the lipid droplet proteome. The research will use multiscale simulations and collaborative experiments to understand how proteins selectively target and interact with lipid droplets in response to varying metabolic conditions. Findings from this work could provide insights to guide future therapeutic interventions for...
This $220,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to advance the understanding of how soft, deformable particles, such as oil droplets and cells, move through complex environments consisting of narrow constrictions and obstacles. The award to Emory University will systematically investigate the flow of bubbles and droplets through obstacle arrays, studying the effects of particle surface tension, obstacle density, size, and...
The University of California, Davis received a $439,105 federal Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) to develop new models and simulations to characterize the collective hydrodynamic behavior of microscopic particles embedded in viscous interfaces. The goal is to establish a rigorous platform to understand and engineer complex membrane-like assemblies, which has applications in areas like drug delivery, respiratory health, and cell biology. The...