Project Grant R01HL175047
Award Date 9/1/26
Completion Date 5/31/30
Dollars Obligated $743K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
Similar Awards
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $1,288,998 on September 12, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate junctophilin-2's role in cardiac fibroblast calcium signaling and injury-induced cardiac fibrosis. The project employs advanced molecular, physiological, and biochemical techniques along with innovative mouse models to elucidate the mechanisms through which junctophilin-2 influences cardiac fibroblasts and...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $631,543 on June 18, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop gene therapies targeting junctophilin-2 for heart failure treatment. The research focuses on restoring excitation-contraction coupling function and correcting maladaptive transcriptional reprogramming in heart failure with reduced ejection fraction. The project leverages adeno-associated virus (AAV) vectors to...
- The National Institutes of Health National Heart Lung and Blood Institute awarded $248,999 to The University of Iowa on July 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support fate-mapping of cardiac monocyte recruitment and specification. The award funds research investigating how diverse macrophage populations obtain their distinct transcriptional profiles following cardiac injury, with the goal of identifying spatiotemporal dynamics of macrophage recruitment...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $143,080 on December 6, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research into the cardiotoxic effects of monoamine oxidase (MAO) metabolism of catecholamines in obesity. The award funds a dissertation project investigating how three reactive metabolites produced by MAO—hydrogen peroxide, ammonia, and catecholaldehydes—individually contribute to mitochondrial dysfunction and...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $599,466 on August 19, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research examining the cellular and molecular mechanisms driving submucosal gland hypertrophy in chronic lung diseases including asthma, COPD, and cystic fibrosis. The funded research will identify fundamental pathways responsible for pathological gland enlargement by defining key cell-cell interactions and signaling...
- The National Heart, Lung, and Blood Institute awarded The University of Iowa $622,619 on August 15, 2026, to conduct research targeting hypothalamic astrocytes in obesity-associated hypertension under the Cardiovascular Diseases Research program (CFDA 93.837, Project Grant R01HL187653). The project investigates how chronic overnutrition alters brain circuits through elevated adipose hormone leptin, causing increased sympathetic outflow and blood pressure elevation. The research focuses on...
- The University of Iowa received a $612,186 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for May 31, 2029. The research investigates the role of lysosomal dysfunction in heart failure with preserved ejection fraction (HFpEF), specifically examining how gamma interferon-inducible thiol reductase (GILT) dysfunction contributes to cardiac immuno-metabolic...
- Federal Grant Award Summary The University of Iowa received a $422,075 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with a completion date of July 31, 2027. The grant funds development of an electromagnetic-actuated dynamic cell culture system designated "MagniWell-12," designed to advance research on airway epithelial cells by simulating physiological stretch-relax...
- Federal Project Grant Award Summary Iowa State University of Science and Technology received a $1.18 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2029. The award funds development of a Scientific Machine Learning (SciML)-accelerated cardiovascular digital twin platform designed to personalize long-term heart valve interventions for valvular heart...
- The National Heart, Lung, and Blood Institute awarded the University of Missouri System $840,770 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the interplay of central and peripheral vascular effects of insulin in obesity. The research focuses on skeletal muscle blood flow impairment and glucose uptake dysregulation in individuals with obesity and insulin resistance. The project examines how central (brain) insulin sensitivity drives sympathetic...