Project Grant R01HL174685

Award Date 9/15/24
Completion Date 8/31/29
Dollars Obligated $689K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60637, USA
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This $684,116 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to examine the mechanisms by which improving sleep regularity affects glycemic control and cardiovascular disease (CVD) risk in adults with type 1 diabetes. The grant will fund a 4-week behavioral sleep stability intervention in 80 adults with type 1 diabetes and irregular sleep...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $524,390 to the University of Colorado-Denver to study the relationship between sleep health, circadian timing, and cardiometabolic risk in adolescents with type 1 diabetes. The research aims to utilize a combined sleep health and circadian timing intervention as a mechanistic probe to...
This Project Grant award of $190,686 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund a longitudinal study to investigate the relationship between sleep characteristics, hypothalamic signaling, and metabolic risk in children. The study aims to translate important findings from animal models to human research by leveraging an established cohort of 200 children...
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $688,800.00 to the University of Chicago to investigate the role of obstructive sleep apnea (OSA) in glycemic dysregulation among adults with type 1 diabetes.

The research study aims to determine how OSA impacts glycemic control in this population and examine the underlying biological mechanisms, such as alterations in counterregulatory hormone release and lipid metabolism. The project will use a rigorous within-subject, cross-over design to compare glycemic control, hormone profiles, and cardiovascular risk markers between untreated OSA and treated OSA conditions in 40 adults with type 1 diabetes. The findings may help identify sleep as a novel intervention target to improve type 1 diabetes management.

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