Project Grant R01HL174651

Award Date 9/6/24
Completion Date 6/30/28
Dollars Obligated $711K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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The key objectives of this 4-year project are to: 1) assess regional brain temperatures and metabolites, including antioxidant levels, in OSA patients compared to healthy controls; 2) determine the relationships between brain temperature, metabolites, and disease severity in OSA; and 3) evaluate changes in brain temperature and metabolites after 6 months of continuous positive airway pressure (CPAP) therapy in OSA patients. The research aims to elucidate the pathological mechanisms by which intermittent hypoxia in OSA leads to oxidative stress, neuroinflammation, and brain tissue damage, which contribute to the autonomic, breathing, mood, and cognitive impairments observed in this condition. The findings could inform the development of targeted interventions, such as anti-inflammatory drugs and antioxidant therapies, to rescue the identified brain changes in OSA patients.

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