This Project Grant award of $624,809.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research aims to investigate the role of dopaminergic regulation of KNDY neurons and its implications for GnRH pulses and polycystic ovary syndrome (PCOS). The research project, conducted by Brigham & Women's Hospital Inc., will examine KNDY neuron activity under normal and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $980,400 to Kent State University to investigate the role of kisspeptin/neurokinin B/dynorphin (KNDY) neurons in an animal model of polycystic ovary syndrome (PCOS). The research aims to define how changes in the regulation of KNDY cells by steroid hormones and afferent...
This $250,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at Colorado State University to investigate the role of maternal gut microbiome and inflammation in preeclampsia and subsequent cardiometabolic disease in offspring. The key research aims are to: 1) Determine if the maternal gut microbiome contributes to pro- or anti-inflammatory short-chain fatty acid signaling at the...
This $147,486 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research to investigate the impact of type 2 diabetes on the vaginal microbiome and its influence on susceptibility to the bacterial pathogen Group B Streptococcus (GBS). The research aims to define the homeostatic characteristics of the vaginal microenvironment in type 2 diabetes, and characterize how the diabetic vaginal microbiome interacts with GBS and...
This $1,046,444 Project Grant was awarded by the U.S. Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (CFDA 10.310) program. The award is funding research and educational activities to: Evaluate the interactions between microbial composition, macromolecular polyphenols, and metabolic signatures related to obesity and chronic disease prevention. This includes both anaerobic fermentation studies and an animal model. Evaluate...
This Project Grant award of $1,332,733, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, supports research to understand the role of preconception lifestyle factors, such as diet, physical activity, and sleep, on pregnancy outcomes. The grantee, the University of Pennsylvania, will leverage the linkage between the National Health and Nutrition Examination Survey (NHANES) and Medicaid...
This $717,285 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund a large-scale investigation of the vaginal ecosystem and its potential role in preeclampsia. The project aims to uncover the microbial, metabolomic, and immune properties of the vaginal microbiome that may indicate, predispose to, or contribute to the development of preeclampsia, a serious...
This federal Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $2,279,811 to Weill Medical College of Cornell University to develop and apply activity-based probes to directly characterize the functional metabolic pathways of the human gut microbiome. The project aims to revolutionize the understanding of the microbiome's role in human health and disease, with a focus on inflammatory bowel disease. Key...
This Project Grant award, totaling $216,736.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project aims to identify the mechanisms by which the host circadian clock and gut microbiome regulate mucus production in the large intestine to protect against infectious and chemical colitis. Key objectives include determining the specific microbiota...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $112,052 to The Trustees of the University of Pennsylvania to conduct research aimed at overcoming treatment resistance in gynecological cancers. The key products and services to be delivered include: Testing new therapies that exploit survival pathways critical for cancers with CCNE1 amplification, which are often platinum-resistant. This includes evaluating biomarkers beyond...
This $1,521,287 Project Grant, awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), will investigate the impact of resistant starch supplementation on cardiometabolic parameters and the gut microbiome in women with polycystic ovary syndrome (PCOS) taking oral contraceptive pills (OCPs). The 4-year study will enroll 100 women with hyperandrogenic PCOS and overweight/obesity in a double-blind, placebo-controlled trial to evaluate how resistant starch in combination with OCPs affects cardiometabolic factors, insulin resistance, inflammation, and specific gut microbes and metabolites compared to OCPs alone. The University of Pennsylvania will conduct the research, with a sub-award to the University of California, San Diego to provide expertise on analyzing gut microbiome and metabolomic data.