Project Grant R01HG014872
- Federal Project Grant Summary Yale University received a $248,823 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded May 1, 2026, with completion targeted for April 30, 2029. This award funds the development of integrative computational models to elucidate the functional consequences of nuclear DNA organization on gene regulation and human health. The project combines machine learning and next-generation...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded New York Genome Center, Inc. (NYGC) a Project Grant of $2,677,663 under the Human Genome Research program (CFDA 93.172), effective June 22, 2026, with completion targeted for May 31, 2030. This award supports the development of NextGen Spatial Multi-Omics Technologies—a cost-effective, user-friendly platform designed to simultaneously profile multiple molecular modalities (including chromatin states,...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded $633,116 to the University of California, Santa Cruz on September 26, 2025, for a project extending through June 30, 2029. This award supports the development of scalable computational methods and tools to advance comparative genomics through analysis of thousands of complete vertebrate genomes. The project will deliver three primary products:...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded Dana-Farber Cancer Institute, Inc. a Project Grant of $501,618 beginning September 1, 2025, and concluding June 30, 2029. This award supports the development of computational tools for variant calling from long genomic and RNA-sequencing (RNA-seq) reads, addressing critical gaps in current genomic analysis methodologies. The project will deliver...
- The National Human Genome Research Institute (NHGRI) awarded a $339,000 Project Grant (CFDA 93.172 - Human Genome Research) to Rockefeller University to develop GFASTAR, a C++ library and tool suite to aid telomere-to-telomere (T2T) genome assembly. The project aims to advance algorithms and software tools for evaluating and manipulating genome assembly graphs, which are essential for generating high-quality, complete, and accurate T2T reference genomes across multiple species. The GFASTAR...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded May 18, 2026, with completion targeted for April 30, 2028. The award funds research on cross-species analysis of regulatory function using synthetic regulatory genomics, specifically advancing understanding of how regulatory DNA sequences function across different...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded the University of Washington $2.324 million in Project Grant funding (Award Date: September 17, 2025; Completion Date: August 31, 2029) to develop computational methods for genotype phasing of large-scale biobank sequence data. The project will deliver two primary methodological innovations: (1) an algorithm that identifies and applies...
- Federal Project Grant Summary Yale University received a $400,000 Project Grant from the National Science Foundation's Division of Computer and Network Systems under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), awarded October 1, 2025, with a completion date of September 30, 2028. Under the PDASP Track 2: Confidential Genome Imputation and Analytics (COGIA) initiative, Yale will develop secure algorithms, software tools, and deployment-ready services that...
- Federal Cooperative Agreement Summary Yale University received a $1,967,182 cooperative agreement from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded May 11, 2026, through April 30, 2029. The award funds development of computational tools and scalable methods for population-scale pangenome construction and analysis. The project addresses cost and privacy barriers that currently limit expansion of the Human Pangenome Reference...
- Federal Project Grant Award Summary The University of Connecticut received an $805,000 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded September 20, 2025, with a completion date of August 31, 2029. This research initiative focuses on developing innovative computational and experimental methodologies for discovering and functionally assessing non-B DNA structures—non-canonical DNA conformations that deviate...
Yale University received a $2.62 million Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded July 6, 2026, with completion targeted for June 30, 2030. The award funds development of advanced computational tools to advance de novo genome assembly—a method for reconstructing genomes without reference constraints—making telomere-to-telomere (T2T) assembly feasible for routine research and clinical applications. The project delivers three integrated product streams. First, Yale will develop a real-time assembly algorithm that optimizes sequencing and assembly simultaneously to enable practical T2T assembly for widespread use. Second, the team will establish an assembly-based framework to reconstruct medically relevant genes with improved accuracy and scalability to support large-cohort studies. Third, Yale will create a comprehensive, reference-free toolkit for assembly-based variant calling and methylation profiling to fully capture genetic variation. Building on the widely used HiFiAsm assembly toolkit, these open-source software tools will enhance speed, affordability, and scalability of assembly-based methods, providing the genomics community with more accurate and user-friendly resources for studying human genetics and identifying complex structural variants in clinically relevant applications.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 7/8/26 |