Project Grant R01HG014458
- The University of Washington was awarded a $2,217,249 federal Project Grant from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) on September 10, 2025 to develop advanced sequence-to-function (S2F) deep learning models that can accurately predict the subtle gene expression consequences arising from natural genetic variations. The project aims to address two key challenges: 1) current models struggle to generalize across diverse genotypes found in personal...
- This Cooperative Agreement award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will provide $1,418,806 to the University of Washington to develop transformative tooling for accurately incorporating epigenetic data into a human pan-genome reference. The key products and services to be delivered include: Developing machine learning models to classify long-read epigenetic data from diverse experimental and sequencing methods. Aggregating long-read...
- The National Human Genome Research Institute (NHGRI) awarded a $400,000 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Washington to develop new single-cell multi-omic technologies for studying the relationship between three-dimensional genome organization and gene expression. Specifically, the grant will fund the development of CARE-Seq, a novel method to jointly measure whole-genome chromatin interactions and gene expression in the same single cells from complex...
- This $2,409,233 federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a suite of advanced statistical tools and user-friendly software to enhance the accuracy and reproducibility of single-cell and spatial omics data analysis. The key products and services to be delivered under this 4-year award include: Statistical methods to generate in silico data for use as negative controls and pseudo-replicates of...
- This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
- This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $196,296 to the University of Chicago to conduct research on the relationship between genetic relatedness and phenotypic covariance. The key objectives are to: 1) Understand how methodological details in computing genetic relatedness matrices may bias heritability estimates at different levels of relatedness, and 2) Develop quantitative genetic models that consider the...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
- The National Human Genome Research Institute (NHGRI) awarded a $579,698 Project Grant (CFDA 93.172 - Human Genome Research) to the Fred Hutchinson Cancer Center in Seattle, Washington to develop the "FACETING GEMS (Genomic Education Modules) for the Entry-Level Workforce" program. The program aims to address the gap in genomics education at under-resourced community colleges by: 1) Providing accessible, research-focused genomics training modules; 2) Training and motivating partner site...
- The University of Florida was awarded a $644,578 Project Grant from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) to develop algorithms that will address challenges and fully enable pangenomics alignment. The key objectives are to: 1) create methods for selecting a subset of genomes from a large population that will achieve the most accurate alignment results, 2) develop a pangenomics scoring scheme to enable alignments from a pangenome, and 3) disseminate...
- This Cooperative Agreement award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $1,310,799 to the University of California, San Diego (UCSD) to develop tools that leverage human reference pangenomes to improve the analysis of complex genetic traits. The key products and services to be delivered include: A web-based pangenome browser that integrates with existing biobank datasets based on linear genomes to enable exploration and visualization of...
The University of Washington received a $2,324,487 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) on September 17, 2025. The purpose of this 4-year project is to develop computational methods for genotype phasing of sequence data from next-generation biobanks containing data for millions of individuals. Key products and services to be delivered under this award include:
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 9/15/25 |